The place is named after the road bridge built in 1879 over the Murray River . Rail traffic also ran over this bridge from 1886 to 1927 before a second bridge was built parallel to it. Today most of the traffic goes over the Swanport Bridge, five kilometers away.
The settlement near the bridge was founded in 1883 and was first called Mobilong, then Edwards Crossing and from 1924 Murray Bridge. The city lives mainly from agriculture and has 16,804 inhabitants.