NOSH aspirin

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Structure of the NOSH compound NBS-1120 : the ASA structure is highlighted in green, the H 2 S releasing structure in yellow and the NO releasing structure in blue

NOSH aspirins are a group of chemical compounds that are structurally derived from acetylsalicylic acid ( aspirin ) and are able to release both nitric oxide (NO) and hydrogen sulfide (H 2 S). They are prodrugs . NO and H 2 S act as gas transmitters in the organism , H 2 S is associated with anti-inflammatory (anti-inflammatory) reactions, NO is involved in maintaining the gastrointestinal mucous membrane.

Acetylsalicylic acid (ASA) has an anticoagulant, analgesic, anti-rheumatic and anti-inflammatory effect in a dose-dependent manner by inhibiting the cyclooxygenases COX-1 and COX-2 . A protective effect against certain types of cancer is controversial. The targeted combination of ASA with NO and H 2 S in a hybrid molecular structure should result in a stronger anti-inflammatory effect and better gastrointestinal tolerance. The compound NBS-1120 (4- (3-thioxo-3 H -1,2-dithiol-5-yl) phenyl-2 - ((4- (nitrooxy) -butanoyl) oxy) benzoate, for example, has a properties comparable to acetylsalicylic acid anti-inflammatory effect and also shows an inhibition of cell growth, which makes the substance interesting for developments in cancer therapy.

Web links

Individual evidence

  1. ↑ a b Kodela, Ravinder; Chattopadhyay, Mitali, Kashfi, Khosrow: NOSH-Aspirin: A Novel Nitric Oxide – Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory Pharmaceuticals. In: ACS Med Chem Lett . 2012 March 8; 3 (3): 257-262. doi : 10.1021 / ml300002m
  2. ^ A b Amjad M. Qandil: Prodrugs of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), More Than Meets the Eye: A Critical Review . In: Int J Mol Sci . 2012; 13 (12): 17244-17274. doi : 10.3390 / ijms131217244