Nestoron
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| Surname | Nestoron | |||||||||
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| Molecular formula | C 23 H 30 O 4 | |||||||||
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| Molar mass | 370.48 g · mol -1 | |||||||||
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | ||||||||||
Nestorone is synthetic progestin , which as a drug for contraception (contraception), as hormone replacement therapy in the menopause and for treatment of endometriosis may be employed.
Unlike other gestagens, Nestoron can penetrate the skin and be applied in the form of a gel, cream, spray or implant ( vaginal ring ). When ingested, the substance is broken down in the gastrointestinal tract and therefore has no effect.
The 19-methyl substitution and the 16-methylene addition in Nestoron strengthen the bond to the progesterone receptor by a factor of 100 compared to progesterone .
In January 2004, a test started in Australia in which Nestoron should be tested in the form of a spray. This spray was developed by the Australian company Acrux and the US non-profit organization Population Council .
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ^ R. Sitruk-Ware: New progestagens for contraceptive use. In: Human Reproduction Update . Volume 12, Number 2, 2006 Mar-Apr, pp. 169-178, doi : 10.1093 / humupd / dmi046 . PMID 16291771 . (Review). PDF .
- ↑ Contraceptive spray in the test. pressetext.austria, November 28, 2003.
Web links
- Clinical Trial: Safety and Efficacy of a Contraceptive Vaginal Ring Delivering Nestorone® and Ethinyl Estradiol
- A. Faúndes, F. Alvarez et al. a .: Correlation of endocrine profiles with bleeding patterns during use of Nestorone contraceptive implants. In: Human reproduction. Volume 14, Number 12, December 1999, pp. 3013-3017, PMID 10601089 , PDF .
