Non-ossifying fibroma

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Non-ossifying fibroma of the tibia on X-ray.
Classification according to ICD-10
M89.8 Other specified bone diseases
ICD-10 online (WHO version 2019)

The non-ossifying fibroma (synonym: fibrous cortical defect (FKD), benign histiocytic fibroma , fibrous metaphyseal defect) is a connective tissue tumor-like bone lesion in children and adolescents. It is a developmental abnormality of the growing bone , not a neoplasm .

In the X-ray image , the NOF usually appears as a diverse, round, grape-like, sharp brightening with a garland-like edge pattern (polycyclic, with garland-shaped edge sclerosis).

It is assumed that the NOF are ossification disorders . The foci consist of collagen-rich connective tissue, fibroblasts , histiocytes and osteoclasts . They are mainly found in the metaphyses of long tubular bones, especially the legs.

In the absence of clinical symptoms , the NOF is almost always an incidental finding . Therapy is not required because spontaneous remission with replacement of the lesions by bone tissue is to be expected.


  • R. Döhler , G. Randzio, S. Schwarte: Diagnostics of non-ossifying fibroids. In: F. Brussatis, K. Hahn (Ed.): Nuclear medicine in orthopedics . Springer, Berlin / Heidelberg 1990, pp. 262-264.
  • A. Heuck: Radiology of bone and joint diseases . Thieme Verlag, 1997, ISBN 3-13-107071-4 .
  • K. Bohndorf, H. Imhof: Radiological diagnosis of bones and joints Thieme, Stuttgart / New York 1998, ISBN 3-13-110982-3 .

Web links

Commons : Non-ossifying Fibroma  - Collection of pictures, videos and audio files

Individual evidence

  1. Alphabetical directory for the ICD-10-WHO Version 2019, Volume 3. German Institute for Medical Documentation and Information (DIMDI), Cologne, 2019, p. 636
  2. [1]
  3. Jürgen Freyschmidt , H. Ostertag, G. Jundt: Bone Tumors. Springer 2003, ISBN 3-540-40364-7 , p. 680 ff.
  4. C. Adler: Bone Diseases. Springer, 1983, ISBN 3-540-62836-3 , p. 314 ff.