The non-ossifying fibroma (synonym: fibrous cortical defect (FKD), benign histiocytic fibroma , fibrous metaphyseal defect) is a connective tissue tumor-like bone lesion in children and adolescents. It is a developmental abnormality of the growing bone , not a neoplasm .
In the X-ray image , the NOF usually appears as a diverse, round, grape-like, sharp brightening with a garland-like edge pattern (polycyclic, with garland-shaped edge sclerosis).
It is assumed that the NOF are ossification disorders . The foci consist of collagen-rich connective tissue, fibroblasts , histiocytes and osteoclasts . They are mainly found in the metaphyses of long tubular bones, especially the legs.
In the absence of clinical symptoms , the NOF is almost always an incidental finding . Therapy is not required because spontaneous remission with replacement of the lesions by bone tissue is to be expected.
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