Non-structural protein

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A non-structural protein (NS abbreviated or NSP, English non-structural protein ) referred to in the virology virus proteins that are not in the structure of the virion are involved, neither the capsid - matrix and membrane proteins of the virus envelope Act.

properties

Non-structural proteins are usually not present in the virion, but can only be detected during the replication of the virus in a host cell . Important exceptions are non-structural proteins such as RNA-dependent RNA polymerase in single-stranded RNA viruses with negative polarity , in which this enzyme must already be present in the virion. Even proteins that are covalently bound to the genome , such as the Parvoviridae or the hepatitis B virus , are non-structural proteins despite their presence in the virion.

Non-structural proteins include any viral polymerases , proteases, or other viral proteins active during the replication cycle. Non-structural proteins also have functions that act on the host cell of the virus, e.g. B. for immune evasion or for maturation or to increase the production rate of newly formed daughter viruses. Examples of non-structural proteins are the non-structural protein 1 and the non-structural protein 2 of the influenza virus or the proteins NSP1 to NSP6 in rotaviruses .

Web links

See also

Individual evidence

  1. ↑ D. M. Knipe, Peter M. Howley (Eds.): Fields Virology . 4th edition, Philadelphia 2001, ISBN 0-7817-6060-7 .
  2. ↑ S. Eifan, E. Schnettler, I. Dietrich, A. Kohl, AL Blomström: Non-structural proteins of arthropod-borne bunyaviruses: roles and functions. In: Viruses. Volume 5, number 10, October 2013, ISSN  1999-4915 , pp. 2447-2468, doi : 10.3390 / v5102447 , PMID 24100888 , PMC 3814597 (free full text).
  3. ↑ L. Hu, SE Crawford, JM Hyser, MK Estes, BV Prasad: Rotavirus non-structural proteins: structure and function. In: Current opinion in virology. Volume 2, number 4, August 2012, ISSN  1879-6265 , pp. 380-388, doi : 10.1016 / j.coviro.2012.06.003 , PMID 22789743 , PMC 3422752 (free full text).