O'Loughlin
O'Loughlin is a family name that may refer to:
- Alex O'Loughlin (born 1976), Australian actor
- David O'Loughlin (* 1978), Irish cyclist
- Ed O'Loughlin (* 19 **), Irish journalist and writer
- Errol O'Loughlin (* 1984), football player from St. Kitts and Nevis
- Gerald S. O'Loughlin (1921-2015), American actor
- Jennifer O'Loughlin (* 1978), American opera singer