Obestatin
| Obestatin | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 23 amino acids | |
| Precursor | Preproghrelin (117 aa) | |
| Identifier | ||
| Gene name | GHRL | |
| External IDs | ||
| Orthologue | ||
| human | House mouse | |
| Entrez | 51738 | 58991 |
| Ensemble | ENSMUSG00000064177 | |
| UniProt | Q9UBU3 | Q9EQX0 |
| Refseq (mRNA) | NM_001134941 | NM_001286404 |
| Refseq (protein) | NP_001128413 | NP_001273333 |
| Gene locus | Chr 3: 10.29-10.29 Mb | Chr 6: 113.72 - 113.73 Mb |
| PubMed search | 51738 |
58991
|
Obestatin is a hormone that is involved in the regulation of food intake by counteracting the effects of the appetite-stimulating ghrelin .
Education and Effects
Obestatin is a peptide hormone that, like its physiological counterpart ghrelin, is released in the stomach from the precursor peptide prepro-ghrelin. There the emptying of the stomach is delayed and the mobility of the duodenum is reduced. It may play a role in the development of obesity , but in animal experiments it has only shown a minor effect on the development of body weight. Whether it is therefore suitable as a drug for the treatment of overweight people has not been conclusively clarified, but it can be doubted.