Bioavailability

The bioavailability is a pharmacological measure of the proportion of an active ingredient which is unchanged in the systemic circulation is (especially in the bloodstream) are available. It indicates how quickly and to what extent the substance (mostly medicinal substance ) is absorbed (resorbed) and is available at the site of action. Bioenhancers can increase the bioavailability of a substance.

For drugs that are administered intravenously, the bioavailability is by definition 100 percent. The absolute bioavailability indicates the bioavailability of a substance applied in any way (e.g. perorally ) in comparison to intravenous administration. The bioavailability observed after oral administration is also called oral bioavailability . The relative bioavailability compares one dosage form with another dosage form (e.g. a tablet with a solution ).

Bioavailability is also an important parameter in pharmacokinetics in the context of drug approval .

Web links

Wikibooks: Pharmacology and Toxicology: Pharmacokinetics  - Learning and Teaching Materials

Individual evidence

1. ^ Peter Langguth, Gert Fricker, Heidi Wunderli-Allenspach: Biopharmazie Wiley-VCH Verlag GmbH & Co. KGaA. Weinheim 2004, ISBN 978-3527304554 , p. 467.
2. ^ Rudolf Voigt, edited by Alfred Fahr : Pharmazeutische Technologie Deutscher Apotheker Verlag. 11th edition. Stuttgart 2010, ISBN 978-3769250039 , p. 223.

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