Oxadiazoles

from Wikipedia, the free encyclopedia

As oxadiazoles members are a group of heterocyclic aromatic refers to compounds that in a five-membered ring system in addition to two carbon - two nitrogen atoms and an oxygen atom included. The four possible isomers differ in the different positions of the two nitrogen atoms.

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presentation

  • 1,2,3-Oxadiazoles can be prepared from α-amino-1,3-dicarbonyl compounds by reaction with nitrous acid (HNO 2 ) and are also referred to as diazooxides . The mesoionic sydnones are special derivatives of the 1,2,3-oxadiazoles .
  • 1,2,4-Oxadiazoles can arise from the reaction of amide oximes with carboxylic acids .
  • 1,2,5-Oxadiazoles ( furazans or furoxanes ) are produced by dehydrating the bis- oximes of 1,2-dicarbonyl compounds ( glyoximes ).
  • 1,3,4-Oxadiazoles are formed in the reaction of diacyl hydrazines with substances that are highly dehydrating, with dehydration .

use

Various derivatives of oxadiazoles are used as drugs ( isradipine , furazabol , raltegravir ), dyes, liquid crystals and scintillators ( PBD = 2-phenyl-5- (4-biphenyl) -1,3,4-oxadiazole). In 2008, oxadiazoles were discovered that are effective against the pair leeches causing schistosomiasis , without any evidence of negative effects on humans.

See also

Individual evidence

  1. ↑ Science-Online-Lexika: Entry on Oxadiazole in the Lexikon der Chemie .
  2. ↑ A glimmer of hope in the fight against schistosomiasis. in: NZZ of March 26, 2008.
  3. ↑ Nature Medicine , online publication March 16, 2008 ( doi : 10.1038 / nm1737 ).

Web links

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