Oyo Mitsunobu

Ōyō Mitsunobu ( Japanese 光 延 旺 洋 Mitsunobu Ōyō ; * 1934 in Tokyo ; † 2003 ) was a Japanese chemist (organic synthesis). In 1967 he introduced the Mitsunobu reaction named after him .

Mitsunobu studied at Gakushuin University in Tokyo with a bachelor's degree and from 1959 at the Tokyo Institute of Technology , where he received his doctorate in 1966 with Teruaki Mukaiyama . He taught at Aoyama Gakuin University in Tokyo.

He dealt with the chemistry of nucleosides and nucleotides and stereoselective reactions.

The Mitsunobu reaction named after him is a substitution of (primary or secondary) alcohols with nucleophiles (in the original reaction an esterification ) and was widely used and used particularly in natural product synthesis and biochemistry. It takes place under relatively mild conditions and is stereospecific. It is an oxidation-reduction condensation in which triphenylphosphine is oxidized and DEA is reduced to its hydrazine (reagents with a similar function to triphenylphosphine and DEA in the original version of the reaction are called Mitsunobu reagents). Mitsunobu introduced the reaction in 1967 and soon developed several variants. Between 1996 and 2008 alone, according to SciFinder, 1615 works with Mitsunobu reaction appeared in the title, including 186 patents.

literature

• Yūki Gōsei Kagaku Kyōkai: My favorite organic synthesis: the 60th anniversary of the Society of Synthetic Organic Chemistry, Kagaku Dojin 2002

Web links

• Chemistry Tree

Individual evidence

1. ↑ O. Mitsunobu, M. Yamada, Bull. Chem. Soc. Japan, Vol. 40, 1967, p. 2380
2. ↑ O. Mitsunobu, M. Yamada, T. Mukaiyama, Bull. Chem. Soc. Japan, Vol. 40, 1967, p. 935
3. ↑ KC Kumara Swamy, NNBhuvan Kumar, E. Balaraman, VP Pavan Kumar, Mitsunobu and related reactions, Chemical Reviews, Volume 109, 2009, pp 2551-2651