Pentapeptide Repeat

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Pentapeptide Repeat

The pentapeptide repeat (in German ' pentapeptide repeat ') is a sequence motif in some proteins .

properties

The Pentapeptide Repeat consists of repeating units of the amino acid sequence Ala - Asp / Asn - Leu and any two amino acids (A (D / N) LXX for short). The function is so far unknown, the Pentapeptide Repeat is possibly a protein-based structural analogue of DNA . Some proteins with a pentapeptide repeat are constructed as a β-helix with an approximately square cross-section.

Individual evidence

  1. ^ A. Bateman, AG Murzin, SA Teichmann: Structure and distribution of pentapeptide repeats in bacteria. In: Protein science: a publication of the Protein Society. Volume 7, number 6, June 1998, pp. 1477-1480, doi : 10.1002 / pro.5560070625 , PMID 9655353 , PMC 2144021 (free full text).
  2. ↑ MW vetting, SS Hegde, Fajardo JE, A. Fiser, SL Roderick, HE Takiff, JS Blanchard: Pentapeptide repeat proteins. In: Biochemistry. Volume 45, number 1, January 2006, pp. 1-10, doi : 10.1021 / bi052130w , PMID 16388575 , PMC 2566302 (free full text).
  3. ↑ a b S. Shah, JG Heddle: Squaring up to DNA: pentapeptide repeat proteins and DNA mimicry. In: Applied Microbiology and Biotechnology . Volume 98, Number 23, December 2014, pp. 9545-9560, doi : 10.1007 / s00253-014-6151-3 , PMID 25343976 .