Pertactin
| Pertactin ( Bordetella pertussis ) | ||
|---|---|---|
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| Ribbon model of the Pertactin from the front and from the side according to PDB 1DAB | ||
| Mass / length primary structure | 677 amino acids | |
| Precursor | Pertactin Auto Exporter (876 AS) | |
| Identifier | ||
| Gene name (s) | prn, ptt; BP1054 | |
| External IDs | ||
| Transporter classification | ||
| TCDB | 1.B.12.2.1 | |
| designation | Car transporter | |
| Occurrence | ||
| Homology family | Pertactin | |
| Parent taxon | Bordetella | |
Pertactin is a protein that in Bordetella - bacteria in the outer cell membrane sits. It is used for attachment ( adhesion ) to host cells (a so-called adhesin ). Pertactin is a human immunogen and antibodies against pertactin show a protective effect against Bordetella infections in animal models . The advantages over established pertussis vaccinations are, however, questioned.
The pertactin precursor contains a β-barrel domain which is separated by peptidases after transport into the periplasm and presumably forms a porin in the outer bacterial membrane through which the separated pertactin part is transported to the outside. Pertactin itself also consists almost exclusively of β-sheets, which together form the largest β-helix known to date .
Individual evidence
- ↑ UniProt P14283
- ↑ Robbins JB, Schneerson R, Keith JM, Miller MA, Kubler-Kielb J, Trollfors B: Pertussis Vaccine: A Critique . In: Pediatr. Infect. Dis. J. . January 2009. doi : 10.1097 / INF.0b013e31818a8958 . PMID 19165133 .
- ^ Emsley P, Charles IG, Fairweather NF, Isaacs NW: Structure of Bordetella pertussis virulence factor P.69 pertactin . In: Nature . 381, No. 6577, May 1996, pp. 90-2. doi : 10.1038 / 381090a0 . PMID 8609998 .
Web links
- PROSITE : Entry car transporter (English)