Phaseolin
α-phaseolin ( Phaseolus vulgaris ) | ||
---|---|---|
Mass / length primary structure | 412 amino acids | |
Secondary to quaternary structure | Homotrimer, glycoprotein | |
Identifier | ||
Gene name (s) | Pha v | |
External IDs | ||
Occurrence | ||
Parent taxon | Phaseolus , Vicia |
β-phaseolin ( Phaseolus vulgaris ) | ||
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Mass / length primary structure | 397 amino acids | |
Secondary to quaternary structure | Homotrimer (dodecamer), glycoprotein | |
Identifier | ||
Gene name (s) | Pha v | |
External IDs | ||
Occurrence | ||
Parent taxon | Phaseolus , Vicia |
Phaseolin (also: Vicilin , Pha v allergen) is the main reserve protein of the bean species (genera Phaseolus and Vicia ), for example also the kidney bean ( Phaseolus vulgaris ). It is a mixture of several glycoproteins that is formed during seed development. It has a share of 30% -50% in the semen proteins and acts as an allergen in humans .
construction
Phaseolin consists of three different proteins (alpha, beta, gamma). All three subspecies are glycoproteins that are bound via N-glycosidic bonds . They belong to the so-called 7S storage proteins .
- Mane (GlcNAc) e.g.
- Man7 (GlcNAc) 2
- Xylose-Man, (GlcNAc)
use
Phaseolin is able to inhibit the activity of the enzyme α-amylase, which is responsible for the breakdown of carbohydrates. Plant extracts containing phaseolin are used because of this nutritional-physiological property in food supplements and medical products and are the subject of various patent applications.
Individual evidence
- ↑ H. E. Paaren et al. : Purification of a seed glycoprotein: N-Terminal and deglycosylation analysis of phaseolin , in: PHYCHEM 26, pp. 335-343 (1987), doi: 10.1016 / S0031-9422 (00) 81410-7
- ↑ Rougé P, Culerrier R, Thibau F, Didier A, Barre A: A case of severe anaphylaxis to kidney bean: phaseolin (vicilin) and PHA (lectin) identified as putative allergens . In: Allergy . 66, No. 2, February 2011, pp. 301-302. doi : 10.1111 / j.1398-9995.2010.02466.x . PMID 20804466 .
- ↑ Arnd Sturm, J. Albert Van Kuik, J. F. G. Vliegenthart, and Maarten J. Chrispeels: Structure, Position, and Biosynthesis of the High Mannose and the Complex Oligosaccharide Side Chains of the Bean Storage Protein Phaseolin , in: THE JOURNAL OF BIOLOGICAL CHEMISTRY, Volume 262, No. 28, edition of October 5, 1987, pp. 13392-13403, PDF , PMID 3654619
- ↑ Comparisons of phaseolin type and α-amylase inhibitor in common bean (Phaseolus vulgaris L.) in China . In: The Crop Journal . tape 4 , no. 1 , February 1, 2016, ISSN 2214-5141 , p. 68–72 , doi : 10.1016 / j.cj.2015.09.002 ( sciencedirect.com [accessed January 16, 2018]).
Web links
- Annika Röcker: Proteins - How peas arm themselves against enemies , on: Spektrum.de from July 24, 2020 (Vicilin)