Phosphoryl group

Phosphoryl group and phosphate group

In chemistry, a phosphoryl group refers to a functional group of the form -PO ₃ ^2- .

properties

In biochemistry , the transfer of a phosphoryl group in the course of phosphorylation to a hydroxyl group (OH group) is a common form of creating an energy-rich bond , for example in the case of the energy supplier adenosine triphosphate (ATP). In the hydrolysis of ATP to AMP and pyrophosphate , the group transfer potential is −45.5 KJ / mol , in the hydrolysis of ATP to ADP and phosphate it is −30.6 KJ / mol. In addition, a phosphoryl group is transferred to phosphoproteins in the course of post-translational modification to activate or inactivate the protein.

In the transfer of a phosphoryl group, a formed organophosphate , OH groups at different or in the case of transmission to a phosphate results in a phosphoric anhydride (the anhydride of phosphoric acid ), and when transmitted to an amino group , a phosphoric acid amide (the amide of phosphoric acid). When a phosphoryl group is transferred to an OH group, the result is a phosphate group .

Individual evidence

1. ↑ Donald Voet, Judith G. Voet: Biochemistry, 4th Edition. John Wiley & Sons, 2010, ISBN 978-1-118-13993-6 . P. 578.
2. ↑ Peter C. Heinrich, Matthias Müller, Lutz Graeve (eds.): Löffler / Petrides Biochemistry and Pathobiochemistry. 9th edition, 2014, Springer. ISBN 978-3642179716 . P. 58.
3. ↑ Jeremy M. Berg, John L. Tymoczko, Lubert Stryer: Biochemistry. 7th edition, Palgrave MacMillan, 2010, ISBN 978-1429276351 . P. 300.
4. ^ Richard Cammack, Teresa Atwood, Peter Campbell, Howard Parish, Anthony Smith, Frank Vella, John Stirling (Eds.): Oxford Dictionary of Biochemistry and Molecular Biology. 2nd edition, 2006, Oxford University Press. ISBN 9780198529170 . P. 519.