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As plasmogamy refers to the fusion of the cell plasma of two cells as part of a sexual process. Usually the gametes fuse first (gametogamy). Usually this is followed by the fusion of the cell nuclei ( karyogamy ), but there are a few exceptions. In the case of plasmogamy of mammalian gametes, only the maternal mitochondrial line in the fertilized egg cell is taken over due to the lack of mitochondria in the sperm cell .