Prausnitz-Küstner experiment
The Prausnitz-Küstner experiment or the Prausnitz-Küstner reaction is a test for an allergy of the immediate type. It shows a local allergic-hyperergic tissue reaction in the non-sensitized after intracutaneous injection of a sterile allergy serum.
Carl Prausnitz and his assistant Heinz Küstner (* 1897) published the results of their self-experiments in 1921: Küstner was allergic to fish and Prausnitz to pollen . When Küstner's serum was injected into Prausnitz's skin, an inflammatory wheal quickly developed there after the injection of fish antigen .
This experiment demonstrated skin-sensitizing antibodies for the first time . In 1925 they were referred to as "Reagine" by Coca and Grove and identified as IgE in 1967 by K. and T. Ishizaka . The Prausnitz-Küstner experiment was an important basis for allergy research and was also used in practice. However, since the transmission of infectious diseases cannot be ruled out, the technically simpler IgE determination has now taken its place.
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- ↑ C. Prausnitz and H. Küstner: Studies on the hypersensitivity. Zbl Bakt 86: 160.
- ↑ Werner E. Gerabek et al .: Encyclopedia of Medical History . Gruyter, 2007. ISBN 3-1101-9703-0
- ↑ K. Ishizaka, T. Ishizaka, WD. Terry: Antigenic structure of gamma-E-globulin and reaginic antibody. J Immunol. 1967 Nov; 99 (5): 849-58. PMID 4169032
- ↑ H.-D. Göring: The passive transmission of immediate type allergy in a self-experiment by Carl Prausnitz and Heinz Küstner - a milestone in allergy research . Akt Dermatol 2007; 33: 87-91.