Propanediol phosphate dehydrogenase
| Propanediol phosphate dehydrogenase | ||
|---|---|---|
| other names |
Propane-1,2-diol-1-phosphate: NAD + oxidoreductase ( NC-IUBMB ) |
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| Identifier | ||
| External IDs |
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| Enzyme classification | ||
| EC, category | 1.1.1.7 , oxidoreductase | |
| Response type | Dehydration | |
| Substrate | 1,2-propanediol-1-phosphate + NAD + | |
| Products | Hydroxyacetone phosphate + NADH + H + | |
| Occurrence | ||
| Parent taxon | Bacteria , oryctolagus | |
Propanediol phosphate dehydrogenase is an enzyme that catalyzes the dehydrogenation of 1,2-propanediol-1-phosphate to hydroxyacetone phosphate in bacteria and Oryctolagus . This enzyme belongs to the family of oxidoreductases , with the hydroxyl group acting as a donor and NAD + as an acceptor . In Oryctolagus cuniculus, this enzyme is mostly localized in the muscle tissue.
properties
The propanediol phosphate dehydrogenase is in microbial cells containing a glycerin - metabolic system include. With the aid of the system and / or a glycerine-absorbing protein, glycerine derivatives can be produced.
Catalyzed equilibrium
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NAD + NADH + H + propanediol phosphate dehydrogenase  |
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| 1,2 propanediol phosphate | Hydroxyacetone phosphate |
Inhibitors
The inhibitors of the enzyme of Oryctolagus cuniculus are: bromide (Br - ), formate (HCOO - ), hydroxyacetone phosphate ( C 3 H 5 O 5 P), phosphate (PO 4 3− ), sulfite (SO 3 2− ) and sulfate ( SO 4 2− ). In the case of hydroxyacetone phosphate, there is competitive inhibition of the product.
Individual evidence
- ↑ Patent EP2041267 : Compositions and methods for enhancing glycerol utilization. Published April 1, 2009 , Inventor: Anamitra Bhattacharyya, Genrich Burd.
- ↑ a b c d e f O. N. Miller: 1,2-Propanediol phosphate (PDP) dehydrogenase . In: Methods Enzymol . 9, 1966, pp. 336-338.
- ↑ a b c d O. Z. Sellinger, ON Miller: The metabolism of acetol phosphate. II. 1,2-Propanediol-1-phosphate dehydrogenase . (PDF) In: J. Biol. Chem. . 234, No. 7, 1959, pp. 1641-1646. PMID 13672935 .