Protectin
| Protectin | ||
|---|---|---|
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| according to PDB 1CDQ | ||
| other names |
1F5 antigen, 20 kDa homologous restriction factor, HRF-20, HRF20, CD59 |
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| Properties of human protein | ||
| Mass / length primary structure | 128 amino acids , 14,177 Da | |
| Identifier | ||
| External IDs | ||
Protectin (synonymous CD59 , MAC-inhibitory protein , MAC-IP , membrane inhibitor of reactive lysis , MIRL ) is a surface protein from the complement system .
properties
Protectin inhibits the formation of the membrane attack complex by binding to complement component C8 and / or complement component C9 , whereby no pore is finally formed. It is also involved in the activation of T cells , in which it is bound to a tyrosine kinase . The soluble form of protectin found in the urine still binds to the complement proteins, but hardly inhibits the development of the membrane attack complex. Protectin has a GPI anchor . By alternative splicing of several arise isoforms .
Mutations that lead to the loss of the GPI anchor reduce the concentration of protectin and decay-accelerating factor on erythrocytes , causing paroxysmal nocturnal hemoglobinuria .
Some enveloped viruses such as HIV , the human cytomegalovirus, and the vaccinia virus use cellular protectin for immune evasion to prevent a complement reaction .
Web links
Individual evidence
- ↑ Huang Y, Qiao F, Abagyan R, Hazard S, Tomlinson S: Defining the CD59-C9 binding interaction . In: J. Biol. Chem. . 281, No. 37, September 2006, pp. 27398-27404. doi : 10.1074 / jbc.M603690200 . PMID 16844690 .
- ↑ Parker C, Omine M, Richards S: Diagnosis and management of paroxysmal nocturnal hemoglobinuria . In: Blood . 106, No. 12, 2005, pp. 3699-709. doi : 10.1182 / blood-2005-04-1717 . PMID 16051736 . PMC 1895106 (free full text).
- ↑ Bohana-Kashtan O, Ziporen L, Donin N, Kraus S, Fishelson Z: Cell signals transduced by complement . In: Mol. Immunol. . 41, No. 6-7, July 2004, pp. 583-597. doi : 10.1016 / j.molimm.2004.04.007 . PMID 15219997 .