Raja Atreya

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Raja Atreya, 2015

Raja Narayana Atreya (born October 15, 1975 in Darmstadt ) is an immunologist and Heisenberg professor for immune research in inflammatory bowel diseases at the Medical Clinic 1 of the University of Erlangen-Nuremberg .

Life

Raja Atreya studied medicine at the University of Mainz between 1995 and 2002 up to the 3rd state examination. As early as 1997 he began in the Mainz group of Markus F. Neurath his thesis that in 2004 with the promotion of doctor of medicine has been completed. Since then, his research has focused on the pathogenesis , diagnosis and therapeutic approaches in inflammatory bowel diseases such as ulcerative colitis and Crohn's disease . In particular, his thesis dealt with the interleukin-6 -mediated apoptosis -resistance of CD4 + - T-lymphocytes in Crohn's disease, with the finding that the blockade of the interleukin-6 signaling pathway repealing experimentally induced colitis leads.

As a doctor in an internship and then as assistant doctor and research assistant to Peter R. Galle , Atreya continued to work in Mainz until 2007, from August 2007 to the end of 2009 he worked there thanks to a post-doctoral fellowship in the DFG-funded graduate college 1043 (“Antigen-specific Immunotherapy ”) again under Markus F. Neurath. With this he moved to Erlangen at the beginning of 2010, where he was appointed professor in August 2010 and has headed the study clinic since October 2012. Since October 2013, he has also been head of the inflammatory bowel disease division at the University Hospital Erlangen as a senior physician. In 2016 Atreya took over the Heisenberg professorship at Erlangen-Nuremberg.

In 2015 he was awarded the Paul Ehrlich and Ludwig Darmstaedter Young Talent Award, which was worth 60,000 euros, for developing a spray made from antibodies . The spray can be used during a colonoscopy in Crohn's disease patients with the aim of predicting whether these patients will respond to therapy with TNF blockers . The background to the research by Raja Atreya was the empirical value that only about every second patient - despite the same clinical picture - responds to the very expensive therapy with TNF blockers. Atreya then assumed that only those drugs can work that actually find their target. For this purpose, he developed the new type of antibody spray, which uses a fluorescent dye to make the relevant binding sites or target molecules visible during a colonoscopy before starting therapy . In a clinical study it could be shown that patients who have many target molecules for a TNF antagonist in their intestinal mucosa respond better to the subsequent therapy than patients with few target molecules.

Honors

Fonts (selection)

  • Raja Atreya et al .: In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease. In: Nature Medicine . Volume 20, 2014, pp. 313-318, doi: 10.1038 / nm.3462
  • Raja Atreya and Martin Goetz: Molecular imaging in gastroenterology. In: Nature Reviews Gastroenterology & Hepatology. Volume 10, 2013, pp. 704-712, doi: 10.1038 / nrgastro.2013.125

Web links

Individual evidence

  1. ↑ Crohn's Disease - Chronic Pain and No Cure. In: Deutsche Welle. July 6, 2018, accessed January 22, 2020 .
  2. ↑ Raja Atreya honored for a novel diagnostic agent for Crohn's disease. Communication from the Paul Ehrlich Foundation of March 14, 2015.
  3. ↑ DGIM awards Theodor Frerichs Prize for Crohn's Disease “Antibody Spray”. On: idw-online from April 28, 2014.
personal data
SURNAME Atreya, Raja
ALTERNATIVE NAMES Atreya, Raja Narayana (full name)
BRIEF DESCRIPTION Immunologist and professor at the University of Erlangen-Nuremberg
DATE OF BIRTH 15th October 1975
PLACE OF BIRTH Darmstadt