TNF blockers

TNF blockers are drugs that are used in the treatment of inflammatory diseases . They are inhibitors of the signaling substance tumor necrosis factor (TNF), which is involved in controlling the cell activity of the immune system . TNF can stimulate cell death , cell and tissue growth , cell differentiation and the release of other signal substances. It triggers a fever and is involved in the development of cachexia in certain diseases. Furthermore, TNF has an effect on lipid metabolism , blood clotting , insulin resistance and endothelial function.

TNF blockers are currently mainly used to treat chronic inflammatory bowel disease, Crohn's disease , chronic inflammatory spinal column disease, ankylosing spondylitis , skin disease psoriasis , joint disease rheumatoid arthritis and Takayasu's arteritis .

The most important medically used representatives of the TNF blockers are the monoclonal antibodies infliximab , adalimumab , golimumab and certolizumab pegol as well as the genetically engineered protein etanercept .

TNF effects are also caused by naturally occurring substances such as For instance by from the turmeric -derived curcumin or in green tea occurring catechins inhibited.

literature

• I. Solovic, M. Sester, JJ Gomez-Reino and a .: The risk of tuberculosis related to tumor necrosis factor antagonist therapies: a TBNET consensus statement . In: Eur. Respir. J. Band 36 , no. 5 , November 2010, p. 1185-1206 , doi : 10.1183 / 09031936.00028510 , PMID 20530046 .
• C. Rivoisy, L. Amrouche et al. a .: Paradoxical exacerbation of tuberculosis after TNFα antagonist discontinuation: beware of immune reconstitution inflammatory syndrome. In: Joint Bone Spine , Volume 78, Number 3, May 2011, pp. 312-315, doi: 10.1016 / j.jbspin.2011.01.003 . PMID 21334948 . (Review).

Individual evidence

1. ↑ A. Gulcubuk, K. Altunatmaz, K. Sonmez and others. a .: Effects of curcumin on tumor necrosis factor-alpha and interleukin-6 in the late phase of experimental acute pancreatitis. In: J Vet Med A Physiol Pathol Clin Med. , 53, 2006, pp. 49-54. PMID 16411910 .
2. ↑ C. Guruvayoorappan, G. Kuttan: (+) - Catechin inhibits tumor angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages. In: Innate Immun. 14, 2008, pp. 160-174. PMID 18562575

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