Rhabdomyosarcoma
| Classification according to ICD-10 | |
|---|---|
| C49 | Malignant growth of other connective tissue and other soft tissue |
| C49.0 | Connective and other soft tissues of the head, face and neck |
| C49.1 | Connective and other soft tissues of the upper extremity, including the shoulder |
| C49.2 | Connective and other soft tissues of the lower extremity, including the hip |
| C49.3 | Connective and other soft tissues of the thorax |
| C49.4 | Connective and other soft tissues of the abdomen |
| C49.5 | Connective and other pelvic soft tissues |
| C49.6 | Connective tissue and other soft tissue of the trunk, unspecified |
| C49.8 | Connective tissue and other soft tissue, overlapping several areas |
| C49.9 | Connective tissue and other soft tissue, unspecified |
| C69 | Malignant neoplasm of the eye and the appendages |
| C69.6 | Orbit |
| C67 | Malignant neoplasm of the urinary bladder |
| C67.0 | Trigonum vesicae |
| C67.1 | Apex vesicae |
| C67.2 | Lateral bladder wall |
| C67.3 | Anterior bladder wall |
| C67.4 | Posterior urinary bladder wall |
| C67.5 | Bladder neck |
| C67.6 | Ureteral ostium |
| C67.7 | Urachus |
| C67.8 | Urinary bladder, overlapping several areas |
| C67.9 | Urinary bladder, unspecified |
| ICD-10 online (WHO version 2019) | |
The rhabdomyosarcoma ( Greek ραβδομυοσάρκωμα rhabdomyosárkoma from rhabdos , the bar 'in terms of histological striation of the skeletal muscles, mys , muscle', SARx , meat ',' soft tissues 'and the ending -om for, tumor formation ') is a highly malignant soft tissue tumor , which originates from degenerate, immature mesenchymal cells. Rhabdomyosarcomas only have in common with all other sarcomas that they are of mesenchymal origin. Histologically, a distinction is made between embryonic, alveolar and pleomorphic (adult) rhabdomyosarcomas based on the growth pattern. The mean 5-year survival of treated patients is over 60 percent and differs between the individual histological types. The localization also influences the prognosis. The main locations are the extremities, head, neck and the urogenital tract.
frequency
About 5% of childhood tumors are rhabdomyosarcomas. Adults are rarely affected.
Symptoms
Depending on the localization, the tumors are noticeable by swelling, abdominal pain or symptoms when urinating (blood loss, pain, etc.).
therapy
Therapeutically, one tries primarily to remove the tumor surgically. This is usually followed by additional radiation therapy. If the tumor is initially inoperable, chemotherapy can be used to reduce the size of the tumor beforehand ( neoadjuvant therapy ). Rhabdomyosarcomas can metastasize or recur in their original location years after treatment (relapse).
See also
literature
- H. Sulser: The rhabdomyosarcoma. In: Virchows Archiv A. Springer, Berlin / Heidelberg, Volume 379, Number 1 / March 1978, pp. 35–71. doi: 10.1007 / BF00432781
- KJ Bühling: Intensive course in general and special pathology. 3rd, updated and extended Edition. Elsevier, Urban & Fischer, Munich 2004, ISBN 3-437-42411-4 .
Web links
- AWMF Guidelines on Malignancies in Children and Adolescents
- PathoPic - Image database of the University of Basel: Rhabdomyosarcoma in a forearm (image of a specimen)
Individual evidence
- ↑ W. Boecker et al .: Pathology . 5th edition. Elsevier Publishing House.
