Seth Grant

Seth GN Grant (* in Sydney ) is an Australian neuroscientist and molecular biologist and Professor of Molecular Neuroscience at the University of Edinburgh . He is known for research on nervous system proteomics .

Life

Seth Grant studied medicine at the University of Sydney with a bachelor's degree (Physiology, Medicine, Surgery) in 1984. 1985 to 1989 he was at the Cold Spring Harbor Laboratory with Douglas Hanahan and 1989 to 1994 as a post-doctoral student at Columbia University with Eric Kandel in which he explored learning and memory in a mouse model. He then worked at the Center for Genome Research at the University of Edinburgh, where he became Professor of Molecular Neuroscience in 2000. From 2003 he was Principal Investigator at the Wellcome Trust Sanger Institute in Cambridge before becoming Professor in Edinburgh again in 2011.

He researches the genes and proteins that are active in synapse function. The list was completed around 2011. He is also researching the phylogenesis of the synapse system (conservative areas that humans have in common with mice, for example) and identified around 130 proteins in the synapse area in which mutations in the associated genes lead to certain mental illnesses and deficits such as schizophrenia, deficiencies in intellectual abilities and autism . His research also showed that the molecules that are important for learning and nervous system plasticity are considerably more complex than previously thought: he showed that an important molecular complex for an ion channel that couples to a neurotransmitter (NMDA receptor complex) can does not have to do with about four, as previously thought, but with 77 subunits and this about ten-fold increase was also evident in other complexes of synapse function.

He is an honorary professor at Cambridge and has been a visiting professor at Melbourne University . He is a Fellow of the Royal Society of Edinburgh . In 2015 he became a Fellow of the Academy of Medical Sciences .

Fonts (selection)

with J. Jessee, FR Bloom, D. Hanahan: Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants, Proc. Nat. Acad. Sci. USA, Vol. 87, 1990, pp. 4645-4649
with TJ O'Dell, Eric Kandel: Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors, Nature, Volume 353, 1991, pp. 558-560
with TJ O'Dell, Eric Kandel u. a.: Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice, Science, Volume 258, 1992, pp. 1903-1910
with R. Brambilla u. a .: A role for the Ras signaling pathway in synaptic transmission and long-term memory, Nature, Volume 353, 1992, pp. 558-560
with M. Migaud a. a .: Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein, Nature, Volume 396, 1998, pp. 433-439
with H. Husi, MA Ward, JS Choudhary, WP Blackstock: Proteomic analysis of NMDA receptor-adhesion protein signaling complexes, Nature Neuroscience, Volume 3, 2000, pp. 661-669
Systems biology in neuroscience: bridging genes to cognition, Current Opinion in Neurobiology, Volume 13, 2003, pp. 577-582.
with H. Husi: Proteomics of multiprotein complexes: answering fundamental questions in neuroscience, Trends in Biotechnology, Volume 19, 2001, Issue 10 Suppl. pp. 49-54
with N. Plath u. a .: Arc / Arg3. 1 is essential for the consolidation of synaptic plasticity and memories, Neuron, Volume 52, 2006, pp. 437-444
with A. Bayes a. a .: Characterization of the proteome, diseases and evolution of the human postsynaptic density, Nature Neuroscience, Volume 14, 2011, pp. 19-21
with M. Hawrylycz u. a .: An anatomically comprehensive atlas of the adult human brain transcriptome, Nature, Volume 489, 2012, pp. 391-399
with G. Kirov a. a .: De novo CNV analysis implicates specific abnormalities of postsynaptic signaling complexes in the pathogenesis of schizophrenia, Molecular Psychiatry, Volume 17, 2012, pp. 142-153
with A. Bayes a. a .: Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins, PloS one 2012, 7; 10; e46683
Synaptopathies: Diseases of the synaptome, Current Opinion in Neurobiology, Volume 22, 2012, pp. 522-529.
with M. Fromer u. a .: De novo mutations in schizophrenia implicate synaptic networks, Nature, Volume 506, 2014, pp. 179-184
with SM Purcell u. a .: A polygenic burden of rare disruptive mutations in schizophrenia, Nature, Volume 506, 2014, pp. 185–190

Web links

Individual evidence

↑ Grant et al. a., Characterization of the proteome, diseases and evolution of the human postsynaptic density, Nature Neuroscience, Volume 14, 2011, pp. 19-21. They identified 1,461 proteins in the postsynaptic density of the neocortex (hPSD) and found 133 mutations in proteins that caused neurological and psychiatric disorders.

personal data
SURNAME	Grant, Seth
ALTERNATIVE NAMES	Grant, Seth GN
BRIEF DESCRIPTION	Australian neuroscientist and molecular biologist
DATE OF BIRTH	20th century
PLACE OF BIRTH	Sydney

[1] Grant et al. a., Characterization of the proteome, diseases and evolution of the human postsynaptic density, Nature Neuroscience, Volume 14, 2011, pp. 19-21. They identified 1,461 proteins in the postsynaptic density of the neocortex (hPSD) and found 133 mutations in proteins that caused neurological and psychiatric disorders.