Shiga-like toxin 1

Shiga-like toxin 2 subunit B
other names	Verocytotoxin 2 subunit B, Verotoxin 2 subunit B
	Existing structure data : PDB 1R4P , PDB 2GA4 , PDB unknown
Mass / length primary structure	89 amino acids , 9,874 Da
Identifier
External IDs	UniProt : P09386 ;

Shiga-like toxin 1 subunit A
other names	Verocytotoxin 1 subunit A, Verotoxin 1 subunit A, rRNA N-glycosidase 1
Mass / length primary structure	315 amino acids , 34,800 Da
Identifier
External IDs	UniProt : P08026 ;
Enzyme classification
EC, category	3.2.2.22

Shiga-like toxin 1 (SLT-1) is a protein from the bacteriophage ϕH19B and a microbial exotoxin .

properties

SLT-1 is closely related to the Shiga-like toxin 2 . Subunit A inactivates the 60S subunits of the ribosomes by hydrolysis of the N -glycosidic bond to an adenine in the 28S rRNA . After endocytosis , the Shiga-like toxin is split into two fragments by the protease furin , A1 and A2. A1 has enzyme activity , while A2 mediates binding to the B subunit. The subunit B binds to the glycolipid globotriaosylceramide ( CD77 ) in the microvilli of the intestine.

^ J. Gariépy: The use of Shiga-like toxin 1 in cancer therapy. In: Critical reviews in oncology / hematology. Volume 39, Numbers 1-2, 2001 Jul-Aug, pp. 99-106, PMID 11418306 .