Silymarin

Silymarin is a mixture of the flavanonol derivatives Silibinin , Isosilibinin, Silicristin and Silidianin.

Extraction

Silymarin is obtained from the fruits of the milk thistle . It was first extracted by Hörhammer in 1930. The active ingredient complex accounts for up to three percent of the dried drug. Silymarin is composed of 20 to 45 percent of silicristin and silidianin, 40 to 65 percent of silibinin A and B and 10 to 20 percent of isosilibinin A and B. Ethyl acetate, acetone, ethanol or methanol are used as extraction agents (if necessary diluted with water).

use

→ Main article : Silibinin

In medicine, silymarin is mainly used for toxic and chronic inflammatory diseases of the liver , e.g. B. in hepatitis C , liver cirrhosis or mushroom poisoning , in which the main ingredient silibinin is effective. The mixture of substances stimulates the activity of RNA polymerase I, stabilizes the lipid structures of the liver cell membrane, has antiperoxidative properties and has antifibrotic effects.

Silymarin is traditionally used for bloating and gas.

literature

• Volker Fintelmann , Rudolf Fritz Weiss : Textbook Phytotherapy. Thieme, 2009. ISBN 978-3-8304-5418-2 . P. 97ff.
• Rudolf Hänsel, Josef Hölzl: Textbook of pharmaceutical biology. Springer-Verlag, Berlin Heidelberg 1996, p. 202.
• Committee on Herbal Medicinal Products (HMPC): Assessment report on Silybum marianum (L.) Gaertn., Fructus (Draft). (As of July 2015)
• Heinz Schilcher : Guide to Phytotherapy. Urban & Fischer, Munich 2007. ISBN 978-3-437-55348-6 . P. 174f.

Web links

• Ulrich Meyer: Milk thistle: beneficial fruits for the liver.
• Cooperation phytopharmaceuticals : milk thistle.
• Research group for monastery medicine : Milk thistle - Silybum marianum Gaert. (Asteraceae).

Individual evidence

1. ↑ Rudolf Hänsel, Josef Hölzl: Textbook of pharmaceutical biology. Springer-Verlag, Berlin Heidelberg 1996. p. 202.
2. ↑ Volker Fintelmann, Rudolf F. Weiss: Textbook Phytotherapy . Georg Thieme Verlag, 2009, ISBN 978-3-8304-5418-2 , p. 8 ( limited preview in Google Book search).
3. ↑ ^{a b} Volker Fintelmann, Rudolf F. Weiss: Textbook Phytotherapy . Georg Thieme Verlag, 2009, ISBN 978-3-8304-5418-2 , p. 97 ff . ( limited preview in Google Book search).
4. ↑ HMPC: Assessment report on Silybum marianum (L.) Gaertn., Fructus (Draft).
5. ↑ HMPC: European Union herbal monograph on Silybum marianum (L.) Gaertn., Fructus (Draft).

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !