Simpson test
The Simpson test is an ophthalmological and neurological examination method for the clinical picture of ocular myasthenia and is usually carried out in conjunction with the so-called tensilon test. The method was named after the Scottish neurologist John Alexander Simpson (1922–2009), who presented decisive results for the study of myasthenia gravis.
execution
In general, with myasthenia gravis, the transmission of nerve signals to the muscle is disturbed, but is temporarily improved by the administration of Tensilon, a short-acting cholinesterase inhibitor . The test now consists of having the patient look up for a few minutes with the head straight to detect ocular myasthenia. In the positive case, fatigue-related, slow lowering of the upper eyelid with partial or complete ptosis results , in some cases also the perception of double images .
After the administration of Tensilon ( Tensilon test ), this symptom of fatigue is temporarily relieved or at least significantly reduced, which, with few exceptions, excludes paralysis from other causes (e.g. Lambert-Eaton-Rooke syndrome ).
Individual evidence
- ^ Albert J. Augustin: Ophthalmology. Berlin: Springer Verlag, 2007, ISBN 978-3-540-30454-8
- ^ Guidelines of the German Society for Neurology
- ↑ Peter Berlit: Clinical Neurology . Springer Verlag 2013, p. 280. ISBN 9783662081181
- ^ AJ Riggs, JE Riggs: "Guessing it right," John A. Simpson, and myasthenia gravis: the role of analogy in science. In: Neurology. Volume 62, Number 3, February 2004, pp. 465-467, PMID 14872032 .
- ↑ Martin R. Turner: Landmark Papers in Neurology Oxford University Press, 2015. pp. 439 ff. ISBN 9780199658602
- ↑ Köhler, Wolfgang; Sieb, Jörn Peter; Kraner, Simone; Schalke, Berthold; Steinlein, Ortrud K .: Myasthenia gravis and myasthene syndrome Deutsches Ärzteblatt 2000; 97 (51-52): A-3496 / B-2938 / C-2616.
- ↑ myasthenia-gravis.de
