Stromal interaction molecule

STIM2 (Homo sapiens)
Properties of human protein
Mass / length primary structure	732 amino acids
Secondary to quaternary structure	Membrane protein (ER, plasma membrane)
Identifier
Gene name	STIM2
External IDs	OMIM : 610841 ; UniProt : Q9P246 ;
Occurrence
Parent taxon	Vertebrates

STIM1 (Homo sapiens)
Properties of human protein
Mass / length primary structure	663 amino acids
Secondary to quaternary structure	Membrane protein (ER, plasma membrane)
Identifier
Gene name	STIM1
External IDs	OMIM : 605921 ; UniProt : Q13586 ;
Occurrence
Parent taxon	multicellular animals

The term stromal interaction molecule (abbreviated to STIM ) describes a protein in cell physiology that, as a calcium sensor, plays a key role in maintaining calcium homeostasis or calcium signaling in animals . In vertebrates there are STIM1 and STIM2, which, as homodimers or heterodimers, form the sensory subunit of the CRAC channel . Mutations in STIM1 - gene are the cause of CRAC channel deficiency and consequent immune deficiency syndrome associated with T-cell inactivation (IDTICED2).

There are two subtypes of STIM: STIM1 and STIM2. Both are membrane proteins , each with a transmembrane domain , which are mainly located in the membrane of the endoplasmic reticulum , but to a lesser extent also in the plasma membrane .

Individual evidence