Stromatoxin
| Kappa-theraphotoxin-Sc1a, ScTx1 | ||
|---|---|---|
| other names |
Stromatoxin-1 |
|
| Mass / length primary structure | 34 amino acids , 3,798 Da | |
| Identifier | ||
| External IDs | ||
Stromatoxin (synonym κ-Theraphotoxin-Sc1a , ScTx1 ) is a protein and toxin from the African tarantula Stromatopelma calceata .
properties
Stromatoxin is produced in the poison glands. It belongs to the family of inhibitor cystine knot - spider toxins . Stromatoxin inhibits voltage-gated potassium channels , including delayed Kv2.1 / KCNB1 ( IC 50 = 12.7 nM), Kv2.1 / Kv9.3 (IC 50 = 7.2 nM, KCNB1 / KCNS3), Kv2.2 / KCNB2 (IC 50 = 21.4 nM) and transient Kv4.2 / KCND2 (IC 50 = 1.2 nM), but not Kv4.1 / KCND1 and Kv4.3 / KCND3 . It has three disulfide bridges . The C terminus of the stromatoxin is amidated .
Web links
Individual evidence
- ↑ a b c P. Escoubas, S. Diochot, ML Célérier, T. Nakajima, M. Lazdunski: Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. In: Molecular pharmacology. Volume 62, Number 1, July 2002, pp. 48-57, PMID 12065754 .