Sulfatides

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The chemical structure of sulfatides

Sulphatides are hydrogen sulphate esters of glycosphingolipids. They are cerebrosides in which a sulfate group is attached to the C 3 of the glycosyl residue (either glucose or galactose ) . The donor is 3'-phosphoadenosine-5'-phosphosulfate (PAPS). They are primarily formed in oligodendrocytes in the CNS . A defect or deficiency in the sulfate-releasing sulfatidase aryl sulfatase A and the resulting accumulation of sulfatides in the lysosomes of oligodendrocytes leads to metachromatic leukodystrophy .

Individual evidence

  1. Entry on sulfatides . In: IUPAC Compendium of Chemical Terminology (the “Gold Book”) . doi : 10.1351 / goldbook.S06093 Version: 2.1.5.

literature

  • G. Löffler, PE Petrides, PC Heinrich: Biochemistry & Pathobiochemistry. 8th edition, Springer, Heidelberg 2006, ISBN 978-3-540-32680-9