3'-phosphoadenosine-5'-phosphosulfate

Structural formula
PAPS in the deprotonated form
General
Surname	3'-phosphoadenosine-5'-phosphosulfate
Molecular formula	C 10 H 15 N 5 O 13 P 2 S
External identifiers / databases
CAS number 482-67-7 EC number 694-699-5 ECHA InfoCard 100.222.927 PubChem 10214 ChemSpider 9799 Wikidata Q229811
properties
Molar mass	507.27 g mol −1
Physical state	firmly
safety instructions
GHS hazard labeling no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

3'-Phosphoadenosine-5'-phosphosulfate or PAPS is an adenosine compound .

The adenosine is phosphorylated at the 3 'and 5' positions and the phosphate group is also connected to a sulfate group at the 5 'position . Therefore, the compound is also known under the name activated sulfuric acid or activated sulfate . The sulfo group (-SO ₃ ^- ) can be transferred to suitable substrates with the help of enzymes sulfotransferases . In this way, PAPS plays an important role in the biosynthesis of natural substances such as carrageenan or heparin as well as in the detoxification of exogenous substances ( xenobiotics ). The sulfonation (mostly) increases the solubility in water so that these so-called conjugates can be more easily excreted by the kidneys .

In the physiological medium, depending on the pH value, the substance is mostly in the anionic form (see structural formula). However, the specified empirical formula, molar mass and CAS registration number refer to the charge-neutral, i.e. fully protonated form.

Individual evidence

1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
2. ↑ Entry on 3′-phosphoadenosine-5′-phosphosulfate. In: Römpp Online . Georg Thieme Verlag, accessed on June 7, 2014.