TlTx3
| Kappa theraphotoxin Tb1c | ||
|---|---|---|
| other names |
Theraphotoxin-3, TlTx3 |
|
| Mass / length primary structure | 35 amino acids , 4,200 Da | |
| Identifier | ||
| External IDs | ||
TlTx3 (synonym Kappa-theraphotoxin-Tb1c ) is a protein and neurotoxin produced by the giant tarantula Theraphosa blondi ( synonym : T. leblondi ).
properties
TlTx3 is formed in the venom glands, like TlTx1 and TlTx2 . It inhibits voltage-gated potassium channels of the type Kv4.2 / KCND2 by shifting the activation of the channel towards greater depolarization . Presumably, TITx3 binds to the S3-S4 linker in the voltage-dependent protein domain of the channel. It is related to heteropodatoxins and phrixotoxins . It has three disulfide bridges .
The toxins TlTx1-3 can be distinguished by mass spectrometry and by Edman degradation .
Web links
Individual evidence
- ↑ J. Ebbinghaus, C. Legros, A. Nolting, C. Guette, ML Celerier, O. Pongs, R. Bähring: Modulation of Kv4.2 channels by a peptide isolated from the venom of the giant bird-eating tarantula Theraphosa leblondi . In: Toxicon: official journal of the International Society on Toxinology. Volume 43, Number 8, June 2004, pp. 923-932, doi : 10.1016 / j.toxicon.2003.12.012 , PMID 15208026 .
- ↑ a b Uniprot : P83747 (TX3_THEBL) .
- ↑ LD Rash, WC Hodgson: Pharmacology and biochemistry of spider venoms. In: Toxicon: official journal of the International Society on Toxinology. Volume 40, Number 3, March 2002, pp. 225-254, PMID 11711120 .
- ↑ C. Legros, ML Célérier, M. Henry, C. Guette: Nanospray analysis of the venom of the tarantula Theraphosa leblondi: a powerful method for direct venom mass fingerprinting and toxin sequencing. In: Rapid communications in mass spectrometry: RCM. Volume 18, number 10, 2004, pp. 1024-1032, doi : 10.1002 / rcm.1442 , PMID 15150824 .