Toponomist

from Wikipedia, the free encyclopedia

With toponome (from ancient Greek τόπος tópos , German , location ' and ancient Greek νόμος -nómos , German , law' ; Engl. Toponomics can see the whole of the molecular networks of cells and tissues, their functional) protein patterns indicate. The new term was created in accordance with genome , the totality of genes, the genetic make-up. He also introduces topological aspects into the description of the highly dynamic (changeable) and complex (multi-layered) biological systems. The word toponom was introduced by Walter Schubert when describing neural networks in the context of proteome research . The English term Toponomics is also a commercially used brand name.

literature

  • W. Schubert: Topological proteomics, toponomics, MELK-technology. In: Adv. Biochem. Closely. Biotechnol. 83, 2003, pp. 189-209. PMID 12934931 .
  • W. Schubert, B. Bonnekoh, AJ Pommer, L. Philipsen, R. Böckelmann, Y. Malykh, H. Gollnick, M. Friedenberger, M. Bode, AW Dress: Analyzing proteome topology and function by automated multidimensional fluorescence microscopy. In: Nat Biotechnol . 24 (10), 2006, pp. 1270-1278. PMID 17013374 .
  • B. Bonnekoh, Y. Malykh, R. Böckelmann, S. Bartsch, AJ Pommer, H. Gollnick: Profiling lymphocyte subpopulations in peripheral blood under efalizumab treatment of psoriasis by multi epitope ligand cartography (MELC) robot microscopy. In: European Journal of Dermatology . 16 (6), 2006, pp. 623-635. PMID 17229602 .
  • B. Bonnekoh, AJ Pommer, R. Böckelmann, H. Hofmeister, L. Philipsen, H. Gollnick: Topo-proteomic in situ analysis of psoriatic plaque under efalizumab treatment. In: Skin Pharmacology and Physiology . 20 (5), 2007, pp. 237-252. PMID 17587888 .
  • U. Berndt, S. Bartsch, L. Philipsen, S. Danese, B. Wiedenmann, AU Dignass, M. Hämmerle, A. Sturm: Proteomic analysis of the inflamed intestinal mucosa reveals distinctive immune response profiles in Crohn's disease and ulcerative colitis. In: J Immunol. 179 (1), 2007, pp. 295-304. PMID 17579049 .
  • U. Berndt, L. Philipsen, S. Bartsch, B. Wiedenmann, DC Baumgart, M. Hämmerle, A. Sturm: Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer. In: Cancer Research . 68 (3), 2008, pp. 880-888. PMID 18245490 .
  • AK Somani, N. Somani: Toponomics: visualizing cellular protein networks in health and disease - 'A single picture is worth more than a thousand words!'. In: Journal of Cutaneous Pathology . 35 (8), 2008, pp. 791-793. PMID 18687076 .

Individual evidence

  1. ↑ smp-proteomics.de ( Memento of the original dated August 12, 2007 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.smp-proteomics.de
  2. ↑ findownersearch.com

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