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schematic cross section of human skin

The term transdermal (from Latin trans "through, through" and Greek derma "skin") is mostly used to describe the administration of medicinal substances for absorption (absorption) through the skin .

The main forms of administration available are transdermal patches . The prerequisite for transdermal absorption is a certain degree of lipophilic properties and a relatively small size of the active substance molecule . Examples of drugs are the opioid fentanyl in pain therapy , nicotine patches for smoking cessation , estrogens for hormone replacement therapy (HRT) and NO- releasing nitro compounds for the treatment of ischemic diseases such as angina pectoris , scopolamine for the treatment of kinetosis (travel sickness) and estrogen / gestagen-active ingredient combinations hormonal contraception .

Individual evidence

  1. Lüllmann et al .: Pharmacology and Toxicology . 15th edition. Thieme Verl. 2003.