Transcription factor IIB
| Transcription factor IIB | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 316 amino acids | |
| Cofactor | Zn 2+ | |
| Identifier | ||
| Gene name | GTF2B | |
| External IDs | ||
| Occurrence | ||
| Homology family | TFIIB | |
| Parent taxon | Euteleostomi | |
The transcription factor IIB (TFIIB) is a protein which in the cell nucleus of vertebrates in DNA binding and the initiation of transcription participates. In particular, TFIIB is responsible for recognizing any BRE element that may be present in the core promoter of the respective gene . During the assembly of the pre-initiation complex , TFIIB binds to the promoter-TFIID-TFIIA complex (DA complex) and thus forms the DAB complex, to which RNA polymerase II docks. TFIIB contains a zinc finger domain for DNA binding .
TFIIB interacts with the center of activity of RNA polymerase. This may prevent the polymerase from docking with the DNA without the pre-initiation complex, thus ensuring positioning accuracy.
TFIIB is also able to form complexes with TCEA2 , GPBP1 , the HIV protein VPR and the Epstein-Barr virus protein EBNA2.
Individual evidence
- ↑ Reinberg / reactome: Binding of TFIIA and TFIIB to the pol II promoter: TFIID complex ( page no longer available , search in web archives ) Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.
- ↑ Deng W, Roberts SG: TFIIB and the regulation of transcription by RNA polymerase II . In: Chromosoma . 116, No. 5, October 2007, pp. 417-29. doi : 10.1007 / s00412-007-0113-9 . PMID 17593382 .
- ^ Tran K, Gralla JD: Control of the timing of promoter escape and RNA catalysis by the transcription factor IIb fingertip . In: J. Biol. Chem. . 283, No. 23, June 2008, pp. 15665-71. doi : 10.1074 / jbc.M801439200 . PMID 18411280 . PMC 2414274 (free full text).
- ↑ UniProt Q00403
