Tropheryma whipplei

Tropheryma whipplei
Systematics
Department :	Actinobacteria
Order :	Actinomycetales
Subordination :	Micrococcineae
Family :	Cellulomonadaceae
Genre :	Tropheryma
Type :	Tropheryma whipplei
Scientific name of the genus
	Tropheryma
	La Scola et al. 2001
Scientific name of the species
	Tropheryma whipplei
	La Scola et al. 2001

Tropheryma whipplei is a gram-positive aerobic rod bacterium from the Cellulomonadaceae family . Usually it is a commensal in the mouth area with no pathogenic symptoms. In some people, probably as a result of defective cellular immunity , the bacteria enter the upper small intestine and a multisystemic disease ( Whipple's disease ) develops .

features

Tropheryma whipplei consists of short aerobic rods that are usually 0.8 to 1.7 µm long and 0.25 to 0.3 µm wide. Flagella are not formed. They are gram-positive and stain well in the PAS reaction , but not with the Ziehl-Neelsen stain , so they are not acid-fast. The bacteria grow mainly within the host cells. When extracellular, the bacterium forms cell aggregates that are embedded in an extracellular matrix .

illness

Genome

Several Tropheryma whipplei have been sequenced so far. The bacterium seems to have a reduced genome compared to other actinobacteria .

Surname

The species name honors the American pathologist George Hoyt Whipple . The generic name comes from the Greek: τροφή trophé - nutrition and ερυμα eryma - hurdle, obstacle, as the bacterium can cause malabsorption .

supporting documents

B. La Scola, F. Fenollar, PE Fournier, M. Altwegg, MN Mallet, D. Raoult: Description of Tropheryma whipplei gen. Nov., Sp. nov., Whipple's disease bacillus. In: Int J Syst Evol Microbiol. 51, 2001, pp. 1471-1479. (online) doi: 10.1099 / 00207713-51-4-1471

Individual evidence

↑ D. Raoult, H. Ogata, S. Audic, C. Robert, K. Suhre, M. Drancourt, J.-M. Claverie: Tropheryma whipplei Twist: a human pathogenic Actinobacteria with a reduced genome. In: Genome Res. 13, 2003, pp. 1800-1809. doi : 10.1101 / gr.1474603 (currently not available) , PMID 12902375 .
Jump up ↑ SD Bentley, M. Maiwald, LD Murphy, MJ Pallen, CA Yeats, LG Dover, HT Norbertczak, GS Besra, MA Quail, DE Harris, A. Von Herbay, A. Goble, S. Rutter, R. Squares, S. Squares, BG Barrell, J. Parkhill, DA Relman: Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei . In: Lancet. 361 2003, pp. 637-644. doi: 10.1016 / S0140-6736 (03) 12597-4 .

Web links

Commons : Tropheryma whipplei - collection of images, videos and audio files

[1] D. Raoult, H. Ogata, S. Audic, C. Robert, K. Suhre, M. Drancourt, J.-M. Claverie: Tropheryma whipplei Twist: a human pathogenic Actinobacteria with a reduced genome. In: Genome Res. 13, 2003, pp. 1800-1809. doi : 10.1101 / gr.1474603 (currently not available) , PMID 12902375 .

[2] Jump up ↑ SD Bentley, M. Maiwald, LD Murphy, MJ Pallen, CA Yeats, LG Dover, HT Norbertczak, GS Besra, MA Quail, DE Harris, A. Von Herbay, A. Goble, S. Rutter, R. Squares, S. Squares, BG Barrell, J. Parkhill, DA Relman: Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei . In: Lancet. 361 2003, pp. 637-644. doi: 10.1016 / S0140-6736 (03) 12597-4 .