Uroplakin-1a
| Uroplakin-1a | ||
|---|---|---|
| other names |
Tetraspanin-21, Tspan-21 |
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| Properties of human protein | ||
| Mass / length primary structure | 258 amino acids , 28,879 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 11045 | |
| Ensemble | ENSG00000105668 | |
| UniProt | O00322 | |
| Refseq (mRNA) | NM_001281443.1 | |
| Refseq (protein) | NP_001268372.1 | |
| PubMed search |
11045
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Uroplakin-1a (synonym Tetraspanin-21 ) is a surface protein from the group of uroplakins and from the group of tetraspanins .
properties
Uroplakin-1a forms homodimers and is part of the asymmetric unit membrane (AUM) of the urothelium . It is mainly formed in cells of the urinary tract and to a lesser extent in the prostate . In cell culture which is gene expression set. In contrast, it is produced in urothelial carcinomas and cell lines thereof. Uroplakin-1a has disulfide bridges and is glycosylated .
Uroplakine
In 1990, Sun's working group examined the components of AUM from the urothelium of the urinary bladder. They were able to identify 3 proteins. A 27-kDa protein was named Uroplakin I, a 15-kDa Uroplakin II and a 47-kDa Uroplakin III. Further research by the working group on uroplakins in cattle showed that Uroplakin I has two isoforms that are 27 kDa ( Uroplakin Ia) and 28 kDa (Uroplakin Ib). Both proteins are glycoproteins, so they have sugar molecules in addition to the amino acid chain. Uroplakin Ia and Uroplakin Ib have about 39% identical amino acid sequences. They have 4 transmembrane domains, i.e. sections that penetrate the cell membrane.
Individual evidence
- ↑ a b c d e UPK1A - Uroplakin-1a - Homo sapiens (Human) - UPK1A gene & protein. In: uniprot.org. November 7, 2018, accessed November 23, 2018 .
- ↑ T. Yuasa, T. Yoshiki, T. Isono, T. Tanaka, H. Hayashida, Y. Okada: Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients. In: International Journal of Urology. Volume 6, Number 6, June 1999, pp. 286-292, PMID 10404304 .
- ↑ ED Lobban, BA Smith, GD Hall, P. Harnden, P. Roberts, PJ Selby, LK Trejdosiewicz, J. Southgate: Uroplakin gene expression by normal and neoplastic human urothelium. In: The American Journal of Pathology . Volume 153, Number 6, December 1998, pp. 1957-1967, doi : 10.1016 / S0002-9440 (10) 65709-4 , PMID 9846985 , PMC 1866332 (free full text).
- ↑ XR Wu, M. Manabe, J. Yu, T.-T. Sun: Large scale purification and immunolocalization of bovine uroplakins I, II, and III. Molecular markers of urothelial differentiation. In: Journal of Biological Chemistry 1990; Volume 265 (Issue 31): P.19170-9. PMID 2229070
- ↑ J. Yu, J.-H. Lin, X.-R. Wu, TT. Sun: Uroplakins Ia and Ib, Two Major Differentiation Products of Bladder Epithelium, Belong to a Family of Four Transmembrane Domain (4TM) Proteins. The Journal of Cell Biology 1994; Volume 125, Issue 1: pp. 171-182. PMID 8138569