Vanillin synthase
| Vanillin synthase | ||
|---|---|---|
| Identifier | ||
| External IDs |
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| Enzyme classification | ||
| EC, category | 4.1.2.41 , lyase | |
| Substrate | 3-hydroxy-3- (4-hydroxy-3-methoxyphenyl) propionyl-CoA | |
| Products | Vanillin, acetyl-CoA | |
| Occurrence | ||
| Parent taxon | Pseudomonas | |
The Vanillinsynthase (VS, EC 4.1.2.41 ) catalyzes the cleavage of 3-hydroxy-3- (4-hydroxy-3-methoxyphenyl) propionyl-CoA in vanillin and acetyl-CoA .
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propanoyl-CoA.svg)
The enzyme belongs to the lyases . It has been identified in some strains of Pseudomonas and Streptomyces viridosporus .
The reaction catalyzed by the VS is an intermediate step in the breakdown of ferulic acid to vanillin. Vanillin is then converted into protocatechuic acid by a further enzymatic reaction . This path is important for lignin degradation. While white rot fungi depolymerize lignin, bacterial microorganisms can further convert the aromatic degradation products that have arisen.
Individual evidence
- ↑ AL Pometto 3rd, DL Crawford: Whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus , in: Appl. Environ. Microbiol. 1983 , 45 , pp. 1582-1585; PMID 6870241 .
- ↑ A. Narbad, MJ Gasson: Metabolism of ferulic acid via vanillin using a novel CoA-dependent pathway in a newly-isolated strain of Pseudomonas fluorescens , in: Microbiology 1998 , 144 , pp. 1397-1405; doi : 10.1099 / 00221287-144-5-1397 ; PMID 9611814 .