WW domain
WW domain | ||
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other names |
WWP or Rsp5 domain |
|
Mass / length primary structure | 38 amino acids |
The WW , WWP domain or also Rsp5 domain is a protein domain of different proteins . It interacts with various protein ligands . It can also bind to proline- rich domains / proteins, to [AP] -PP- [AP] -Y and to domains that contain phosphoserine - phosphothreonine .
Structure and occurrence
The WW domain folds into a stable, three-stranded β-sheet . It is relatively short with just 38 amino acids and is repeated up to four times in certain proteins such as in human NEDD4 . Its name is derived from the presence of two tryptophan residues (abbreviated with "W"), which are located about 20-23 amino acids apart and which occur in most of the known WW domains. Hydrophobic residues form a flat spot that serves to bind with proline.
The WW domain was first discovered when the two connected isoforms of YAP (“Yes associated protein”) YAP1-1 and YAP1-2 were examined more closely. YAP1-2 differs from YAP1-1 in that it has 38 more amino acids. These 38 amino acids were called the WW domain (actually they represent the second WW domain of YAP1-2 ).
The WW domain occurs in the following proteins, among others:
- YAP
- Dystrophin
- Utrophin
- NEDD4 (mouse)
- RSP5 (baker's yeast)
- FE65 (rat)
- DB10 (tobacco)
- FBP11 (with formin as binding partner)
Individual evidence
- ↑ SMART: WW
- ↑ HI Chen and M. Sudol: The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules . In: Proceedings of the National Academy of Sciences . 92, No. 17, August 1995, pp. 7819-7823. doi : 10.1073 / pnas.92.17.7819 . PMID 7644498 . PMC 41237 (free full text).
- ↑ a b c InterPro : IPR001202 (English)
- ↑ a b c WW domain . The Pawson Lab , accessed August 21, 2015.
- ↑ M. Sudol, P. Bork, A. Eindond, K. Kastury, T. Druck, M. Negrini, K. Huebner and D. Lehman: Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain . In: The Journal of Biological Chemistry . 270, No. 24, June 1995, pp. 14733-14741. doi : 10.1074 / jbc.270.24.14733 . PMID 7782338 .
- ↑ P. Bork and M. Sudol: The WW domain: a signaling site in dystrophin? . In: Trends in Biochemical Sciences . 19, No. 12, December 1994, pp. 531-533. doi : 10.1016 / 0968-0004 (94) 90053-1 . PMID 7846762 .