WW domain

from Wikipedia, the free encyclopedia
WW domain
other names

WWP or Rsp5 domain

Mass / length primary structure 38 amino acids

The WW , WWP domain or also Rsp5 domain is a protein domain of different proteins . It interacts with various protein ligands . It can also bind to proline- rich domains / proteins, to [AP] -PP- [AP] -Y and to domains that contain phosphoserine - phosphothreonine .

Structure and occurrence

The WW domain folds into a stable, three-stranded β-sheet . It is relatively short with just 38 amino acids and is repeated up to four times in certain proteins such as in human NEDD4 . Its name is derived from the presence of two tryptophan residues (abbreviated with "W"), which are located about 20-23 amino acids apart and which occur in most of the known WW domains. Hydrophobic residues form a flat spot that serves to bind with proline.

The WW domain was first discovered when the two connected isoforms of YAP (“Yes associated protein”) YAP1-1 and YAP1-2 were examined more closely. YAP1-2 differs from YAP1-1 in that it has 38 more amino acids. These 38 amino acids were called the WW domain (actually they represent the second WW domain of YAP1-2 ).

The WW domain occurs in the following proteins, among others:

Individual evidence

  1. ↑ SMART: WW
  2. ↑ HI Chen and M. Sudol: The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules . In: Proceedings of the National Academy of Sciences . 92, No. 17, August 1995, pp. 7819-7823. doi : 10.1073 / pnas.92.17.7819 . PMID 7644498 . PMC 41237 (free full text).
  3. ↑ a b c InterPro : IPR001202 (English)
  4. ↑ a b c WW domain . The Pawson Lab , accessed August 21, 2015.
  5. ↑ M. Sudol, P. Bork, A. Eindond, K. Kastury, T. Druck, M. Negrini, K. Huebner and D. Lehman: Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain . In: The Journal of Biological Chemistry . 270, No. 24, June 1995, pp. 14733-14741. doi : 10.1074 / jbc.270.24.14733 . PMID 7782338 .
  6. ↑ P. Bork and M. Sudol: The WW domain: a signaling site in dystrophin? . In: Trends in Biochemical Sciences . 19, No. 12, December 1994, pp. 531-533. doi : 10.1016 / 0968-0004 (94) 90053-1 . PMID 7846762 .