Zbtb7
| Zbtb7 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 584 amino acids | |
| Identifier | ||
| Gene name | ZBTB7A | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Vertebrates | |
Zbtb7 ( Zinc finger and BTB domain-containing protein 7 , originally Pokemon ) is a cancer-promoting protein in vertebrates , which is encoded by the ZBTB7 gene (located on chromosome 19p13.3). The first discovery was published in Nature in 2005 . The substance suppresses the transcription of certain proteins and thus indirectly inhibits the function of the tumor suppressor proteins RB and p53 .
The original name Pokemon stands for " POK e rythroid m yeloid on togenic factor" and is a Backronym the Pokémon series of movies and games. After a complaint from Nintendo and Pokémon USA in December 2005, the standard designation "Pokemon" was withdrawn, since then it has been called "Zbtb7".
Individual evidence
- ↑ Homologues at OMA
- ↑ Jai A. Dennison: Switching Off 'Pokemon' Gene May Block Cancer-Cell Formation , Daily News Central. January 20, 2005. Archived from the original on February 7, 2012. Retrieved June 27, 2006.
- ↑ Takahiro Maeda, Robin M. Hobbs, et al .: Role of the proto-oncogene Pokemon in cellular transformation and ARF repression . In: Nature . 433, No. 433, January 20, 2005, pp. 278-285. doi : 10.1038 / nature03203 . PMID 15662416 . Retrieved June 27, 2006.
- ↑ Brendan Sinclair: Pokémon USA threatens to sue cancer researchers . GameSpot . December 19, 2005. Archived from the original on July 22, 2011. Retrieved June 27, 2006.