Zerewitinov's reaction
The Zerewitinow reaction or Zerewitinoff reaction is understood to mean the determination of active hydrogen atoms in a chemical compound.
For this purpose, a methyl magnesium halide, i.e. a Grignard reagent , is reacted with the compound to be examined. It reacts with acidic hydrogen to form a magnesium salt and the corresponding hydrocarbon . The methane produced is determined gas volumetrically . Compounds with an acidic or active H atom can be, for example, water, alcohols , amines or alkynes .
Examples:
- general reaction of methylmagnesium bromide with water:
- general reaction of methylmagnesium bromide with an alcohol:
- Reaction of methyl magnesium iodide with propyne , whose hydrogen atom on the sp carbon atom is acidic:
The reaction is named after the Russian chemist Fyodor Wassiljewitsch Zerewitinow (1874–1947).
Individual evidence
- ↑ a b Hans Peter Latscha, Uli Kazmaier and Helmut Alfons Klein: Organic Chemistry: Basic Chemistry II . Springer Verlag; 6th completely revised edition. 2008, p. 200, ISBN 978-3540771067 .