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'''''A Time for Choosing''''', also known as "''The Speech,''" was presented on a number of speaking occasions during the [[U.S. presidential election, 1964|1964 U.S. presidential election campaign]] by future-[[President of the United States|president]] [[Ronald Reagan]] on behalf of [[Republican Party (United States)|Republican]] candidate [[Barry Goldwater]].
A '''psychostimulant''' is a substance that enhances locomotor behavior. Examples of psychostimulants include [[amphetamine]], [[methamphetamine]],<ref name="urlDorlands Medical Dictionary:psychostimulant">{{cite web |url=http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/seven/000088218.htm |title=Dorlands Medical Dictionary:psychostimulant |format= |work= |accessdate=}}</ref> [[cocaine]], [[methylphenidate]], and [[arecoline]], the most widely used psychostimulant.<ref>{{cite journal |author=Gupta PC, Ray CS |title=Epidemiology of betel quid usage |journal=Ann. Acad. Med. Singap. |volume=33 |issue=4 Suppl |pages=31–6 |year=2004 |month=July |pmid=15389304 |doi= |url=http://www.annals.edu.sg/pdf200409/V33N4p31S.pdf}}</ref>


Many versions of the speech exist, as it was altered during many stops, but two are best known:
[[Nicotine]] and [[caffeine]] are not considered psychostimulants because they do not enhance locomotor behavior in rodents.<ref name="Mechanisms-Sulzer">{{cite journal |author=Sulzer D, Sonders MS, Poulsen NW, Galli A |title=Mechanisms of neurotransmitter release by amphetamines: a review |journal=Prog. Neurobiol. |volume=75 |issue=6 |pages=406–33 |year=2005 |pmid=15955613 |doi=10.1016/j.pneurobio.2005.04.003}}</ref>
*[[1964 Republican National Convention]] - [[San Francisco, California]] - Given as a nomination speech for Goldwater.
*As part of a pre-recorded [[television]] program titled "Rendezvous with Destiny", broadcast on [[October 27]], [[1964]].


Following the speech, Ronald Reagan was asked to run for [[governor of California]]. To this day, this speech is considered one of the most effective ever made on behalf of a candidate. Reagan was later called the "''great communicator''" in recognition of his effective communication skills.
Psychostimulants are often potent modulators of [[dopamine]] signaling, often affecting the activity of [[monoamine transporter]]s such as the [[dopamine transporter]] and [[vesicular monoamine transporter]]s.<ref>{{cite journal |author=Riddle EL, Fleckenstein AE, Hanson GR |title=Role of monoamine transporters in mediating psychostimulant effects |journal=The AAPS journal |volume=7 |issue=4 |pages=E847–51 |year=2005 |pmid=16594636 |doi=10.1208/aapsj070481}}</ref>


==References==
==External links==
*[http://www.americanrhetoric.com/speeches/ronaldreaganatimeforchoosing.htm Transcript, audio, and video of the broadcast]
{{reflist}}


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{{Major drug groups}}
{{Ronald Reagan}}
{{Psychostimulants, agents used for ADHD and nootropics}}
[[Category:Drugs]]
[[Category:Ronald Reagan]]
[[category:stimulants]]
[[Category:Speeches]]


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[[fr:Psychostimulant]]

Revision as of 17:27, 13 October 2008

A Time for Choosing, also known as "The Speech," was presented on a number of speaking occasions during the 1964 U.S. presidential election campaign by future-president Ronald Reagan on behalf of Republican candidate Barry Goldwater.

Many versions of the speech exist, as it was altered during many stops, but two are best known:

Following the speech, Ronald Reagan was asked to run for governor of California. To this day, this speech is considered one of the most effective ever made on behalf of a candidate. Reagan was later called the "great communicator" in recognition of his effective communication skills.

External links