Myelophthisic anemia: Difference between revisions
m clean up, typos fixed: occuring → occurring using AWB |
|||
| Line 1: | Line 1: | ||
{{Infobox_Disease |
{{Infobox_Disease |
||
| Name = |
| Name = Myelophthisic anemia |
||
| Image = |
| Image = |
||
| Caption = |
| Caption = |
||
| Line 20: | Line 19: | ||
==Diagnosis== |
==Diagnosis== |
||
The first test for diagnosis myelophthisis involves looking at a small sample of blood under a microscope. Myelophthisis is suggested by the presence of red blood cells that contain [[cell nucleus|nuclei]] or are teardrop-shaped (poikilocytotic cells), or immature [[granulocyte]] precursor cells which indicates leukoerythroblastosis is |
The first test for diagnosis myelophthisis involves looking at a small sample of blood under a microscope. Myelophthisis is suggested by the presence of red blood cells that contain [[cell nucleus|nuclei]] or are teardrop-shaped (poikilocytotic cells), or immature [[granulocyte]] precursor cells which indicates leukoerythroblastosis is occurring because the displaced hematopoietic cells begin to undergo extramedullary hematopoiesis. These immature granulocytes are seen in peripheral blood smears. Diagnosis is confirmed when a bone marrow biopsy demonstrates significant replacement of the normal bone marrow compartment by fibrosis, malignancy or other infiltrative process. The presence of immature blood cell precursors helps distinguish another cause of [[pancytopenia]], [[aplastic anemia]], from myelophthisic anemia because in aplastic anemia the hematopoietic cells are damaged and immature blood cells are not seen in the peripheral blood. |
||
==Treatment== |
==Treatment== |
||
Treatment of this disorder involves treatment of the underlying cancer.<ref>American Society of hematology self-assessment program, second edition, 2005, page 82.</ref> |
Treatment of this disorder involves treatment of the underlying cancer.<ref>American Society of hematology self-assessment program, second edition, 2005, page 82.</ref><ref name="titleMyelophthisic Anemia: Anemias Caused by Deficient Erythropoiesis: Merck Manual Professional">{{cite web |url=http://www.merck.com/mmpe/sec11/ch130/ch130g.html |title=Myelophthisic Anemia: Anemias Caused by Deficient Erythropoiesis: Merck Manual Professional |accessdate=2008-03-08 |format= |work=}}</ref> |
||
==Presentation== |
==Presentation== |
||
| Line 35: | Line 34: | ||
==References== |
==References== |
||
{{reflist|2}} |
{{reflist|2}} |
||
| ⚫ | |||
| ⚫ | |||
[[Category:Blood disorders]] |
[[Category:Blood disorders]] |
||
| Line 40: | Line 42: | ||
{{disease-stub}} |
{{disease-stub}} |
||
| ⚫ | |||
| ⚫ | |||
Revision as of 13:18, 30 June 2009
| Myelophthisic anemia | |
|---|---|
| Specialty | Hematology  |
Myelophthisic anemia (or myelophthisis) is a severe kind of anemia found in some people with diseases that affect the bone marrow. Myelophythisis refers to the displacement of hemopoietic bone-marrow tissue into the peripheral blood,[1] either by fibrosis, tumors or granulomas.
Causes
Myelophythisis can occur in the setting of chronic myeloproliferative disoders, leukemia, lymphoma, and metastatic carcinoma or myeloma. It is common in people who have chronic idiopathic myelofibrosis. It has been linked to small-cell lung cancer, breast cancer or prostate cancer that metastasizes to the bone marrow.[2]
Diagnosis
The first test for diagnosis myelophthisis involves looking at a small sample of blood under a microscope. Myelophthisis is suggested by the presence of red blood cells that contain nuclei or are teardrop-shaped (poikilocytotic cells), or immature granulocyte precursor cells which indicates leukoerythroblastosis is occurring because the displaced hematopoietic cells begin to undergo extramedullary hematopoiesis. These immature granulocytes are seen in peripheral blood smears. Diagnosis is confirmed when a bone marrow biopsy demonstrates significant replacement of the normal bone marrow compartment by fibrosis, malignancy or other infiltrative process. The presence of immature blood cell precursors helps distinguish another cause of pancytopenia, aplastic anemia, from myelophthisic anemia because in aplastic anemia the hematopoietic cells are damaged and immature blood cells are not seen in the peripheral blood.
Treatment
Treatment of this disorder involves treatment of the underlying cancer.[3][4]
Presentation
Historically, the most common displacement of the healthy bone marrow was from tuberculosis.[citation needed]
There may be evidence of extramedullary hematopoiesis[5] (marrow elements can be found in the spleen, liver).
Etiology
Myelophthisis is thought to be related to the release of cytokines that simulate fibroblastic proliferation and fibrosis in the marrow.[6]
References
- ^ "Hematopathology".
- ^ American Society of hematology self-assessment program, second edition, 2005, page 82.
- ^ American Society of hematology self-assessment program, second edition, 2005, page 82.
- ^ "Myelophthisic Anemia: Anemias Caused by Deficient Erythropoiesis: Merck Manual Professional". Retrieved 2008-03-08.
- ^ Makoni SN, Laber DA (2004). "Clinical spectrum of myelophthisis in cancer patients". Am. J. Hematol. 76 (1): 92–3. doi:10.1002/ajh.20046. PMID 15114608.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ American Society of hematology self-assessment program, second edition, 2005, page 82.
{{Diseases of RBCs and megakaryocytes}} may refer to:
- {{Diseases of RBCs}}, a navigational template for diseases of red blood cells
- {{Diseases of megakaryocytes}}, a navigational template for diseases of clotting
If an internal transclusion led you here, you may wish to change it to point directly to the intended page.
{{Template disambiguation}} should never be transcluded in the main namespace.
 | This article about a disease, disorder, or medical condition is a stub. You can help Wikipedia by expanding it. |