MT-ATP8: Difference between revisions
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[[File:Map of the human mitochondrial genome.svg|thumb|320px|Location of the ''MT-ATP8'' gene in the human mitochondrial genome. ''MT-ATP8'' is one of the two ATP synthase mitochondrial genes (red boxes).]] |
[[File:Map of the human mitochondrial genome.svg|thumb|320px|Location of the ''MT-ATP8'' gene in the human mitochondrial genome. ''MT-ATP8'' is one of the two ATP synthase mitochondrial genes (red boxes).]] |
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| ⚫ | [[File:Homo sapiens-mtDNA~NC 012920-ATP8+ATP6 Overlap.svg |
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{{Infobox protein family |
{{Infobox protein family |
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| Symbol = ATP-synt_8 |
| Symbol = ATP-synt_8 |
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==The gene== |
==The gene== |
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| ⚫ | [[File:Homo sapiens-mtDNA~NC 012920-ATP8+ATP6 Overlap.svg|thumb|400px|The 46-nucleotide overlap in the reading frames of the human mitochondrial genes ''MT-ATP8'' and ''MT-ATP6''. For each nucleotide triplet (square brackets), the corresponding amino acid is given (one-letter code), either in the +1 frame for ''MT-ATP8'' (in red) or in the +3 frame for ''MT-ATP6'' (in blue).]] |
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The ATP synthase protein 8 of human and other mammals is encoded in the [[mitochondrial genome]] by the ''MT-ATP8'' [[gene]]. When the complete human mitochondrial genome was first published, the ''MT-ATP8'' gene was described as the unidentified [[Reading frame#Open reading frame|reading frame]] ''[[Unidentified reading frame|URF]] A6L''.<ref name="pmid7219534">{{cite journal |vauthors=Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG | title = Sequence and organization of the human mitochondrial genome | journal = Nature | volume = 290 | issue = 5806 | pages = 457–65 |date=April 1981 | pmid = 7219534 | doi = 10.1038/290457a0| url = }}</ref> |
The ATP synthase protein 8 of human and other mammals is encoded in the [[mitochondrial genome]] by the ''MT-ATP8'' [[gene]]. When the complete human mitochondrial genome was first published, the ''MT-ATP8'' gene was described as the unidentified [[Reading frame#Open reading frame|reading frame]] ''[[Unidentified reading frame|URF]] A6L''.<ref name="pmid7219534">{{cite journal |vauthors=Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG | title = Sequence and organization of the human mitochondrial genome | journal = Nature | volume = 290 | issue = 5806 | pages = 457–65 |date=April 1981 | pmid = 7219534 | doi = 10.1038/290457a0| url = }}</ref> |
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Revision as of 21:00, 3 August 2018
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| Aliases | ATP8, ATPase8, MTMT-ATP synthase F0 subunit 8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 516070; MGI: 99926; HomoloGene: 124425; GeneCards: ATP8; OMA:ATP8 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| ATP synthase protein 8 (metazoa) | |||||||||
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| Identifiers | |||||||||
| Symbol | ATP-synt_8 | ||||||||
| Pfam | PF00895 | ||||||||
| Pfam clan | CL0255 | ||||||||
| InterPro | IPR001421 | ||||||||
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| Plant ATP synthase F0 subunit 8 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | YMF19 | ||||||||
| Pfam | PF02326 | ||||||||
| Pfam clan | CL0255 | ||||||||
| InterPro | IPR003319 | ||||||||
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| Fungal ATP synthase protein 8 (A6L) | |||||||||
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| Identifiers | |||||||||
| Symbol | Fun_ATP-synt_8 | ||||||||
| Pfam | PF05933 | ||||||||
| Pfam clan | CL0255 | ||||||||
| InterPro | IPR009230 | ||||||||
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ATP synthase protein 8 is a subunit of mitochondrial ATP synthase. Subunit 8 differs in sequence between Metazoa, plants and Fungi.
The protein
This protein subunit appears to be an integral component of the stator stalk in yeast mitochondrial F-ATPases.[5] The stator stalk is anchored in the membrane, and acts to prevent futile rotation of the ATPase subunits relative to the rotor during coupled ATP synthesis/hydrolysis. This subunit may have an analogous function in Metazoa.
The gene
The ATP synthase protein 8 of human and other mammals is encoded in the mitochondrial genome by the MT-ATP8 gene. When the complete human mitochondrial genome was first published, the MT-ATP8 gene was described as the unidentified reading frame URF A6L.[6]
An unusual feature of the MT-ATP8 gene is its 46-nucleotide overlap with the MT-ATP6 gene. With respect to the reading frame (+1) of MT-ATP8, the MT-ATP6 gene starts on the +3 reading frame.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000228253 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064356 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Stephens AN, Khan MA, Roucou X, Nagley P, Devenish RJ (May 2003). "The molecular neighborhood of subunit 8 of yeast mitochondrial F1F0-ATP synthase probed by cysteine scanning mutagenesis and chemical modification". J. Biol. Chem. 278 (20): 17867–75. doi:10.1074/jbc.M300967200. PMID 12626501.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG (April 1981). "Sequence and organization of the human mitochondrial genome". Nature. 290 (5806): 457–65. doi:10.1038/290457a0. PMID 7219534.
Further reading
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