Prenyltransferase

Prenyltransferase and squalene oxidase repeat
Structure of a squalene cyclase.
Identifiers
Symbol	Prenyltrans
Pfam	PF00432
Pfam clan	CL0059
InterPro	IPR001330
PROSITE	PDOC00825
SCOP2	1sqc / SCOPe / SUPFAM
OPM protein	1w6k
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 1w6kA:122-165 1w6jA:122-165 1o6qA:59-102 1umpC:59-102 1h39A:59-102 1h3cB:59-102 2sqcA:59-102 1h37A:59-102 1o6hA:59-102 1gszA:59-102 3sqcA:59-102 1o79A:59-102 1h35A:59-102 1h3aC:59-102 1h36A:59-102 1h3bA:59-102 1o6rB:59-102 1sqc :59-102 1s64L:142-186 1tnuJ:142-186 1n4qH:142-186 1n4pD:142-186 1n4sL:142-186 1n4rH:142-186 1tnzL:142-186 1tnyL:142-186 1tnbD:142-186 1tnoH:142-186 1dceD:114-157 1ltxB:114-157 1jcqB:172-215 1mzcB:172-215 1s63B:172-215 1sa4B:172-215 1ld7B:172-215 1ld8B:172-215 1tn6B:172-215 2ftiB:172-215 1fppB:172-215 1n9aB:172-215 1nl4B:172-215 1hz7B:172-215 1o5mB:172-215 1n94B:172-215 1kzoB:172-215 1jcrB:172-215 1o1rB:172-215 1ni1B:172-215 1sa5B:172-215 1ftiB:172-215 1qbqB:172-215 1d8dB:172-215 1ft2B:172-215 1ft1B:172-215 1o1sB:172-215 1d8eB:172-215 1tn8B:172-215 1qe2B:172-215 1x81B:172-215 1kzpB:172-215 1tn7B:172-215 1kzrB:172-215 1jcsB:172-215 3ftiB:172-215 1o1tB:172-215 1n95B:172-215

Prenyltransferases are a class of enzymes that transfer allylic prenyl groups to acceptor molecules. Prenyl transferases commonly refer to prenyl diphosphate synthases.

Prenyltransferases are commonly divided into two classes, cis (or Z) and trans (or E), depending upon the stereo chemistry of the resulting products. Examples of trans-prenyltranferases include dimethylallyltranstransferase, and geranylgeranyl pyrophosphate synthase. Cis-prenyltransferases include dehydrodolichol diphosphate synthase (involved in the production of a precursor to dolichol).

The beta subunit of the farnesyltransferases is responsible for peptide binding. Squalene-hopene cyclase is a bacterial enzyme that catalyzes the cyclization of squalene into hopene, a key step in hopanoid (triterpenoid) metabolism. Lanosterol synthase (EC 5.4.99.7) (oxidosqualene-lanosterol cyclase) catalyzes the cyclization of (S)-2,3-epoxysqualene to lanosterol, the initial precursor of cholesterol, steroid hormones and vitamin D in vertebrates and of ergosterol in fungi. Cycloartenol synthase (EC 5.4.99.8) (2,3-epoxysqualene-cycloartenol cyclase) is a plant enzyme that catalyzes the cyclization of (S)-2,3-epoxysqualene to cycloartenol.

Human proteins containing this domain

FNTB; LSS; PGGT1B; RABGGTB

Further reading

• Wendt KU, Poralla K, Schulz GE (1997). "Structure and function of a squalene cyclase". Science (journal). 277 (5333): 1811–5. doi:10.1126/science.277.5333.1811. PMID 9295270. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
• Poralla K, Hewelt A, Prestwich GD, Abe I, Reipen I, Sprenger G (1994). "A specific amino acid repeat in squalene and oxidosqualene cyclases". Trends Biochem. Sci. 19 (4): 157–8. doi:10.1016/0968-0004(94)90276-3. PMID 8016864. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

External links

• Prenyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Protein prenyltransferases alpha subunit repeat in PROSITE

This article incorporates text from the public domain Pfam and InterPro: IPR001330