Dolichole

General structure of dolicholes with n = 2 ( trans configuration) and m = 10 to 16 ( cis configuration).

Dolichole is a group of polyunsaturated isoprenoid compounds that consist of four or more isoprene units, with the α-isoprene unit being saturated and carrying a primary hydroxyl group (−OH). Dolichols are thus derivatives of polyprenols , ie 2,3-dihydropolyprenols. Most of the double bonds in longer-chain compounds have the cis configuration , but trans configurations also occur in the molecule .

They play a role in the cotranslational modification of proteins , especially in their N -glycosylation in the endoplasmic reticulum .

Web links

• Description of the N -glycosylation of proteins on the website of Birkbeck, University of London ( English )

Individual evidence

1. ^ Entry on Dolichole. In: Römpp Online . Georg Thieme Verlag, accessed on February 20, 2018.
2. ↑ Entry on dolichols . In: IUPAC Compendium of Chemical Terminology (the “Gold Book”) . doi : 10.1351 / goldbook.D01829 Version: 2.3.3.