Thiaminase
| Thiaminase I. | ||
|---|---|---|
| Enzyme classification | ||
| EC, category | 2.5.1.2 , transferase | |
| Substrate | Thiamine + pyridine | |
| Products | 1 - [(4-Amino-2-methylpyrimidin-5-yl) methyl] pyridinium + 4-methyl-5- (2-hydroxyethyl) thiazole | |
| Occurrence | ||
| Parent taxon | some eukaryotes | |
| Thiaminase II | ||
|---|---|---|
| Enzyme classification | ||
| EC, category | 3.5.99.2 , hydrolase | |
| Substrate | Thiamine + H 2 O | |
| Products | a pyrimidine + a thiazole | |
| Occurrence | ||
| Parent taxon | bacteria | |
Thiaminases are enzymes found in several types of bacteria , in some fish, and in plants such as bracken ( Pteridium aquilinum ). The enzymes, if ingested with food over the long term, can destroy the vitamin B 1 ( thiamine ) in the food and lead to deficiency symptoms ( hypovitaminoses ) and thus to diseases such as beri-beri . Cooking destroys thiaminase.
Individual evidence
- ↑ NcCleary BV and Chick BF .: The purification and properties of a thiaminase I from Nardoo (Marsilea drummondii) . In: Phytochemistry . 16, 1977, pp. 207-213. doi : 10.1016 / S0031-9422 (00) 86787-4 .
- ↑ Boś M, Kozik A: Some molecular and enzymatic properties of a homogeneous preparation of thiaminase I purified from carp liver . In: J Protein Chem . 19, No. 2, 2000, pp. 75-84. doi : 10.1023 / A: 1007043530616 . PMID 10945431 .