4'-hydroxynorendoxifene

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Structural formula
General
Surname	4'-hydroxynorendoxifene
other names	N , N -didesmethyl-4,4'-dihydroxytamoxifen 4,4 ′ - {1- [4- (2-Aminoethoxy) phenyl] but-1-en-1,2-diyl} diphenol ( IUPAC )
Molecular formula	C 24 H 25 NO 3
External identifiers / databases
CAS number 1679327-22-0 ChemSpider 58967386 Wikidata Q30314598
properties
Molar mass	375.468 g mol −1
safety instructions
GHS labeling of hazardous substances H and P phrases H: ? EUH: ? P: ?
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

4'-hydroxynorendoxifene is a synthetic , nonsteroidal antiestrogen with a triphenylethylene basic structure. It is a dual selective estrogen receptor modulator (SERM) and aromatase inhibitor (AI) and was derived from tamoxifen , a SERM, and norendoxifen, a metabolite of tamoxifen that functions as AI. The drug has been suggested for possible development as a treatment for estrogen receptor (ER) positive breast cancer . It was synthesized in 2015.

Individual evidence

1. ↑ Wei Lv, Jinzhong Liu, Todd C. Skaar, David A. Flockhart, Mark Cushman: Design and Synthesis of Norendoxifen Analogues with Dual Aromatase Inhibitory and Estrogen Receptor Modulatory Activities . In: Journal of Medicinal Chemistry . tape 58 , no. 6 , February 9, 2015, p. 2623-2648 , doi : 10.1021 / jm501218e .
2. ↑ Siddavaram Nagini: Breast Cancer: Current Molecular Therapeutic Targets and New Players . In: Anti-Cancer Agents in Medicinal Chemistry . tape 17 , no. 2 , January 12, 2017, p. 152-163 , doi : 10.2174 / 1871520616666160502122724 .