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4'-hydroxynorendoxifene is a synthetic , nonsteroidal antiestrogen with a triphenylethylene basic structure. It is a dual selective estrogen receptor modulator (SERM) and aromatase inhibitor (AI) and was derived from tamoxifen , a SERM, and norendoxifen, a metabolite of tamoxifen that functions as AI. The drug has been suggested for possible development as a treatment for estrogen receptor (ER) positive breast cancer . It was synthesized in 2015.
Individual evidence
↑ Wei Lv, Jinzhong Liu, Todd C. Skaar, David A. Flockhart, Mark Cushman: Design and Synthesis of Norendoxifen Analogues with Dual Aromatase Inhibitory and Estrogen Receptor Modulatory Activities . In: Journal of Medicinal Chemistry . tape58 , no.6 , February 9, 2015, p.2623-2648 , doi : 10.1021 / jm501218e .