6-phosphogluconolactonase
6-phosphogluconolactonase | ||
---|---|---|
Properties of human protein | ||
Mass / length primary structure | 258 amino acids | |
Identifier | ||
Gene names | PGLS ; 6PGL | |
External IDs | ||
Enzyme classification | ||
EC, category | 3.1.1.31 , hydrolase | |
Response type | hydrolysis | |
Substrate | 6-phosphogluconolactone + H 2 O | |
Products | 6-phosphogluconate | |
Occurrence | ||
Homology family | Phosphogluconolactonase | |
Parent taxon | Creature |
6-phosphogluconolactonase (6PGL) ( gene : PGLS ) is the enzyme that hydrolyzes 6-phosphogluconolactone to 6-phosphogluconate . This reaction is the second sub-step in the pentose phosphate pathway . 6PGL occurs in most living things.
The expression of 6PGL is increased in breast cancer cells, as a proteomics study was able to show.
Catalyzed reaction
6-phosphogluconolactone is hydrolyzed to 6-phosphogluconate. Although the lactone hydrolyses on its own, it has a certain stability so that it could have undesirable reactions during its lifetime. This is remedied by the 6PGL.
Individual evidence
- ↑ UniProt O95336
- ↑ Ou K, Yu K, Kesuma D, et al : Novel breast cancer biomarkers identified by integrative proteomic and gene expression mapping . In: J. Proteome Res . 7, No. 4, April 2008, pp. 1518-28. doi : 10.1021 / pr700820g . PMID 18318472 .
- ↑ Miclet E, Stoven V, Michels PA, Opperdoes FR, Lallemand JY, Duffieux F: NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase . In: J. Biol. Chem. . 276, No. 37, September 2001, pp. 34840-6. doi : 10.1074 / jbc.M105174200 . PMID 11457850 .
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Hexose Monophosphate Pathway - Learning and Teaching Materials