6-phosphogluconolactonase

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6-phosphogluconolactonase
Properties of human protein
Mass / length primary structure 258 amino acids
Identifier
Gene names PGLS  ; 6PGL
External IDs
Enzyme classification
EC, category 3.1.1.31 hydrolase
Response type hydrolysis
Substrate 6-phosphogluconolactone + H 2 O
Products 6-phosphogluconate
Occurrence
Homology family Phosphogluconolactonase
Parent taxon Creature

6-phosphogluconolactonase (6PGL) ( gene : PGLS ) is the enzyme that hydrolyzes 6-phosphogluconolactone to 6-phosphogluconate . This reaction is the second sub-step in the pentose phosphate pathway . 6PGL occurs in most living things.

The expression of 6PGL is increased in breast cancer cells, as a proteomics study was able to show.

Catalyzed reaction

6PG-lactone+ H 2 O    6PG

6-phosphogluconolactone is hydrolyzed to 6-phosphogluconate. Although the lactone hydrolyses on its own, it has a certain stability so that it could have undesirable reactions during its lifetime. This is remedied by the 6PGL.

Individual evidence

  1. UniProt O95336
  2. Ou K, Yu K, Kesuma D, et al : Novel breast cancer biomarkers identified by integrative proteomic and gene expression mapping . In: J. Proteome Res . 7, No. 4, April 2008, pp. 1518-28. doi : 10.1021 / pr700820g . PMID 18318472 .
  3. Miclet E, Stoven V, Michels PA, Opperdoes FR, Lallemand JY, Duffieux F: NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase . In: J. Biol. Chem. . 276, No. 37, September 2001, pp. 34840-6. doi : 10.1074 / jbc.M105174200 . PMID 11457850 .

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