6-phosphogluconolactone

Structural formula
6-phosphogluconolactone under physiological conditions
General
Surname	6-phosphogluconolactone
other names	6-phosphoglucono-δ-lactone
Molecular formula	C 6 H 11 O 9 P
External identifiers / databases
CAS number 2641-81-8 PubChem 439452 Wikidata Q245503
properties
Molar mass	256.10 g mol −1
safety instructions
GHS hazard labeling no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

6-phosphogluconolactone is a chemical compound that occurs as an intermediate in the pentose phosphate pathway . In the first step of the pentose phosphate pathway, the enzyme glucose-6-phosphate dehydrogenase (G6PDH) catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone. The enzyme's cofactor is NADP ⁺ , which is reduced to NADPH / H ⁺ :

${\displaystyle \mathrm {Glucose{\text{-6-}}phosphat+NADP^{+}{\xrightarrow {G6PDH}}} }$ ${\displaystyle \mathrm {6{\text{-}}Phosphogluconolacton+NADPH+H^{+}\;\!} }$

Since this reaction is supposed to generate reduction equivalents in the form of NADPH , which are required in other metabolic synthesis pathways such as fatty acid biosynthesis , glucose-6-phosphate dehydrogenase is specifically responsible for the conversion of NADP ⁺ to NADPH. NAD ⁺ can therefore not be used as a cofactor.

Catalyzed reaction

+ NADP ⁺ ⇒ + NADPH / H ⁺

Glucose-6-phosphate is oxidized at the C1 atom by means of the cofactor NADP ⁺ . In the next step of the pentose phosphate pathway, 6-phosphogluconolactone is hydrolyzed to 6-phosphogluconate.

See also

• Gluconolactone

literature

• Donald Voet, Judith G. Voet, Charlotte W. Pratt: Textbook of Biochemistry . Translation edited by Annette G. Beck-Sickinger and Ulrich Hahn. Wiley-VCH Verlag, 2002

Individual evidence

1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.