AGM region

The AGM region is a region in the developing vertebrate - embryo . AGM stands for aorta , gonads and mesonephros . The region includes the dorsal aorta, the surrounding mesenchyme, and the urogenital ridge . It arises from a structure called the splanchnopleura , which is part of the mesoderm (lateral plate mesoderm). In this region there are specialized endothelial cells , from which hematopoietic stem cells arise, which play an important role in the formation of blood cells ( hematopoiesis ).

Web links

• For Splanchnopleura: Online embryology course for medical students. Developed by the Universities of Friborg, Lausanne and Bern (Switzerland) with the support of the Swiss Virtual Campus.
• AGM region in the Cytokines & Cells Online Pathfinder Encyclopaedia (in English).

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1. ↑ HK Mikkola, SH Orkin: The journey of developing hematopoietic stem cells . In: Development . tape 133 , no. October 19 , 2006, p. 3733-3744 , doi : 10.1242 / dev.02568 , PMID 16968814 .